| Define: | A progressive, degenerative neurologic disease characterized by a TREMOR that is maximal at rest, retropulsion (i.e. a tendency to fall backwards), rigidity, stooped posture, slowness of voluntary movements, and a masklike facial expression. Pathologic features include loss of melanin containing neurons in the substantia nigra and other pigmented nuclei of the brainstem. LEWY BODIES are present in the substantia nigra and locus coeruleus but may also be found in a related condition (LEWY BODY DISEASE, DIFFUSE) characterized by dementia in combination with varying degrees of parkinsonism. (Adams et al., Principles of Neurology, 6th ed, p1059, pp1067-75) | A synucleinopathy that has_material_basis_in degeneration of the central nervous system that often impairs motor skills, speech, and other functions. |
| Alias: | Idiopathic Parkinson Disease//Idiopathic Parkinson's Disease//Lewy Body Parkinson Disease//Lewy Body Parkinson's Disease//Paralysis Agitans//Parkinson Disease, Idiopathic//Parkinson's Disease//Parkinson's Disease, Idiopathic//Parkinson's Disease, Lewy Body//Primary Parkinsonism | paralysis agitans//Parkinson disease |