The tsRNA and Disease Database (version 1.0)
| Disease | DO_ID | DO_Name | DO_Type | DO_Define |
|---|---|---|---|---|
| Alzheimer Disease | DOID:10652 | Alzheimer's disease | disease of anatomical entity | A tauopathy that is characterized by memory lapses, confusion, emotional instability and progressive loss of mental ability and results in progressive memory loss, impaired thinking, disorientation, and changes in personality and mood starting and leads in advanced cases to a profound decline in cognitive and physical functioning and is marked histologically by the degeneration of brain neurons especially in the cerebral cortex and by the presence of neurofibrillary tangles and plaques containing beta-amyloid. |
| Amyotrophic Lateral Sclerosis | DOID:332 | amyotrophic lateral sclerosis | disease of anatomical entity | A motor neuron disease that is characterized by muscle spasticity, rapidly progressive weakness due to muscle atrophy, difficulty in speaking, swallowing, and breathing. |
| Atherosclerosis | DOID:1936 | atherosclerosis | disease of anatomical entity | N/A |
| Cardiomegaly | N/A | N/A | N/A | N/A |
| Carotid Artery Injuries | DOID:3407 | carotid artery disease | disease of anatomical entity | N/A |
| Fetal Growth Retardation | N/A | N/A | N/A | N/A |
| Heart Failure | N/A | N/A | N/A | N/A |
| Intracranial Aneurysm | DOID:10941 | intracranial aneurysm | disease of anatomical entity//nervous system disease | N/A |
| Ischemia | DOID:326 | ischemia | disease of anatomical entity | A vascular disease that is characterized by a restriction in blood supply to tissues. |
| Mitochondrial Diseases | N/A | N/A | N/A | N/A |
| Moyamoya disease | DOID:13099 | Moyamoya disease | disease of anatomical entity//nervous system disease | A cerebral arterial disease characterized by constriction of certain arteries at the base of the brain. Blood flow is blocked by the constriction and also by blood clots. |
| Moyamoya Disease | DOID:13099 | Moyamoya disease | disease of anatomical entity//nervous system disease | A cerebral arterial disease characterized by constriction of certain arteries at the base of the brain. Blood flow is blocked by the constriction and also by blood clots. |
| Multiple Sclerosis | DOID:2377 | multiple sclerosis | disease of anatomical entity//nervous system disease | A demyelinating disease that involves damage to the fatty myelin sheaths around the axons of the brain and spinal cord resulting in demyelination and scarring. |
| Multiple Sclerosis, Relapsing-Remitting | DOID:2378 | relapsing-remitting multiple sclerosis | disease of anatomical entity//nervous system disease | A multiple sclerosis that is characterized by relapse (attacks of symptom flare-ups) followed by remission (periods of recovery). Symptoms may vary from mild to severe, and relapses and remissions may last for days or months. More than 80 percent of people who have MS begin with relapsing-remitting cycles. |
| Myocardial Infarction | DOID:5844 | myocardial infarction | disease of anatomical entity | A coronary artery disease characterized by myocardial cell death (myocardial necrosis) due to prolonged ischaemia. |
| Neurodegenerative Diseases | DOID:1289 | neurodegenerative disease | disease of anatomical entity | A central nervous system disease that results in the progressive deterioration of function or structure of neurons. |
| Obesity | DOID:9970 | obesity | disease of metabolism | An overnutrition that is characterized by excess body fat, traditionally defined as an elevated ratio of weight to height (specifically 30 kilograms per meter squared), has_material_basis_in a multifactorial etiology related to excess nutrition intake, decreased caloric utilization, and genetic susceptibility, and possibly medications and certain disorders of metabolism, endocrine function, and mental illness. |
| Osteoporosis | DOID:11476 | osteoporosis | disease of anatomical entity | A bone resorption disease characterized by decreased density of normally mineralized bone which results_in the thinning of bone tissue and decreased mechanical strength. |
| Parkinson Disease | DOID:14330 | Parkinson's disease | disease of anatomical entity | A synucleinopathy that has_material_basis_in degeneration of the central nervous system that often impairs motor skills, speech, and other functions. |
| Rheumatic Heart Disease | DOID:0050827 | rheumatic heart disease | disease of anatomical entity | A heart valve disease that is characterized by repeated inflammation with fibrinous repair caused by an autoimmune reaction to Group A beta-hemolytic streptococci (GAS) that results in valvular damage. The cardinal anatomic changes of the valve include leaflet thickening, commissural fusion, and shortening and thickening of the tendinous cords. |
| Spinal Cord Injuries | N/A | N/A | N/A | N/A |
| Stroke | N/A | N/A | N/A | N/A |
| Vascular Remodeling | N/A | N/A | N/A | N/A |