Entry Detail


General Information

Database ID:TRD05395
Confidence:Very High
Contents:>> tsRNA Information
>> tsRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference



tsRNA Information

tsRNA Name:tRF-3031B
tsRNA Type:N/A
Amino acid and Anticodon:N/A
Sequence:N/A
Related Target:RELA
Predicted Target:N/A
External Links:
MINTbase ID:N/A
tRFdb ID:N/A



tsRNA Association Statistics

Total Associated Disease Number:1
More Information
Network:
(Display the first 15 nodes)



Disease Information

 MeSHDisease Ontology
Disease ID:D010003DOID:8398
Disease Name:Osteoarthritisosteoarthritis
Category:MeSHDisease Ontology
Type:Musculoskeletal Diseases//Musculoskeletal Diseasesdisease of anatomical entity
Define:A progressive, degenerative joint disease, the most common form of arthritis, especially in older persons. The disease is thought to result not from the aging process but from biochemical changes and biomechanical stresses affecting articular cartilage. In the foreign literature it is often called osteoarthrosis deformans.An arthritis that has_material_basis_in worn out cartilage located_in joint.
Alias:Arthritis, Degenerative//Arthroses//Arthrosis//Osteoarthrosis//Osteoarthrosis Deformansdegenerative arthritis//degenerative joint disease//hypertrophic arthritis//Osteoarthrosis and allied disorder//osteoarthrosis



Disease Association Statistics

Total Associated tsRNA Number:87
More Information
Network:
(Display the first 15 nodes)



Evidence Support

Strong Evidence:PCR//Western blot
Weak Evidence:tRF and tiRNA arrays



Reference

[1] PubMed ID:39222756
Disease Name:Osteoarthritis
Tissue:Osteoarthritis
Dysfunction Pattern:Down-Regulation
Validated Method:PCR//Western blot//tRF and tiRNA arrays
Description:The results showed that tRF-3031B, tRF-3008B,3′tiR_088_LysCTT, tRF-50008C,and tRF-3030B exhibited low expression levels in anterior cruciate ligament cells.
Comparision:Disease VS Control
Mechanism:The results showed that tRF-3031B was expressed at low levels in OA ACL and Interleukin-1β (IL-1β) treated ACL cells. We found that RELA was the target of tRF-3031B. When ACL cells were transfected with tRF-3031B mimics, RELA expression was suppressed, whereas transfection with tRF-3031B inhibitors had the opposite effect. The rescue and dual-luciferase reporter assays showed that tRF-3031B silenced the RELA expression by binding to its untranslated region (3′-UTR).