tsRNADisease

Entry Detail

General Information

Database ID:	TRD04606
Confidence:	High
Contents:	>> tsRNA Information >> tsRNA Association Statistics >> Disease Information >> Disease Association Statistics >> Evidence Support >> Reference

tsRNA Information

tsRNA Name:

tiRNA-Gly-GCC

tsRNA Type:

N/A

Amino acid and Anticodon:

GlyGCC

Sequence:

N/A

Related Target:

Predicted Target:

External Links:

MINTbase ID:	N/A
tRFdb ID:	N/A

tsRNA Association Statistics

Total Associated Disease Number:	22 More Information
Network: (Display the first 15 nodes)

Disease Information

	MeSH	Disease Ontology
Disease ID:	D050197	DOID:1936
Disease Name:	Atherosclerosis	atherosclerosis
Category:	MeSH	Disease Ontology
Type:	Cardiovascular Diseases	disease of anatomical entity
Define:	A thickening and loss of elasticity of the walls of ARTERIES that occurs with formation of ATHEROSCLEROTIC PLAQUES within the ARTERIAL INTIMA.	N/A
Alias:	N/A	N/A

Disease Association Statistics

Total Associated tsRNA Number:	271 More Information
Network: (Display the first 15 nodes)

Evidence Support

Strong Evidence:	RT-PCR//Western blot
Weak Evidence:	High-throughput sequencing

Reference

[1] PubMed ID:	36818350
Disease Name:	Atherosclerosis
Tissue:	Arterial Tissues
Dysfunction Pattern:	Up-Regulation
Validated Method:	RT-PCR//Western blot//High-throughput sequencing
Description:	tiRNA-Gly-GCC is upregulated in synthetic HASMCs, atherosclerotic arteries, plasma, and the balloon injured carotid artery of rats.
Comparision:	Disease VS Normal
Mechanism:	Mechanistically, tiRNA-Gly-GCC performs these functions on HASMCs via downregulating chromobox protein homolog 3 (CBX3). Finally, the inhibition of tiRNA-Gly-GCC could ameliorate neointimal formation after vascular injury in vivo.