Entry Detail


General Information

Database ID:TRD04139
Confidence:High
Contents:>> tsRNA Information
>> tsRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference



tsRNA Information

tsRNA Name:tRF-5022B
tsRNA Type:tRF-5
Amino acid and Anticodon:N/A
Sequence:N/A
Related Target:N/A
Predicted Target:N/A
External Links:
MINTbase ID:N/A
tRFdb ID:N/A



tsRNA Association Statistics

Total Associated Disease Number:1
More Information
Network:
(Display the first 15 nodes)



Disease Information

 MeSHDisease Ontology
Disease ID:D010003DOID:8398
Disease Name:Osteoarthritisosteoarthritis
Category:MeSHDisease Ontology
Type:Musculoskeletal Diseases//Musculoskeletal Diseasesdisease of anatomical entity
Define:A progressive, degenerative joint disease, the most common form of arthritis, especially in older persons. The disease is thought to result not from the aging process but from biochemical changes and biomechanical stresses affecting articular cartilage. In the foreign literature it is often called osteoarthrosis deformans.An arthritis that has_material_basis_in worn out cartilage located_in joint.
Alias:Arthritis, Degenerative//Arthroses//Arthrosis//Osteoarthrosis//Osteoarthrosis Deformansdegenerative arthritis//degenerative joint disease//hypertrophic arthritis//Osteoarthrosis and allied disorder//osteoarthrosis



Disease Association Statistics

Total Associated tsRNA Number:87
More Information
Network:
(Display the first 15 nodes)



Evidence Support

Strong Evidence:PCR//Western blot
Weak Evidence:Sequencing



Reference

[1] PubMed ID:37880787
Disease Name:Osteoarthritis
Tissue:serum
Dysfunction Pattern:Down-Regulation
Validated Method:PCR//Western blot//Sequencing
Description:The findings demonstrated that tRF-5022B expression was considerably lower in OA serum. The Kellgren–Lawrence grading scale was shown to correspond with serum expression levels. The ROC curve confirmed that tRF-5022B serum expression levels might differentiate OA cases from healthy individuals and RA patients. According to the aforementioned findings, tRF-5022B may be employed as a novel biomarker for OA diagnosis due to its excellent diagnostic value.
Comparision:Disease VS Control
Mechanism:N/A