The tsRNA and Disease Database (version 1.0)
| Disease | DO_ID | DO_Name | DO_Type | DO_Define |
|---|---|---|---|---|
| Alzheimer Disease | DOID:10652 | Alzheimer's disease | disease of anatomical entity | A tauopathy that is characterized by memory lapses, confusion, emotional instability and progressive loss of mental ability and results in progressive memory loss, impaired thinking, disorientation, and changes in personality and mood starting and leads in advanced cases to a profound decline in cognitive and physical functioning and is marked histologically by the degeneration of brain neurons especially in the cerebral cortex and by the presence of neurofibrillary tangles and plaques containing beta-amyloid. |
| Amyotrophic Lateral Sclerosis | DOID:332 | amyotrophic lateral sclerosis | disease of anatomical entity | A motor neuron disease that is characterized by muscle spasticity, rapidly progressive weakness due to muscle atrophy, difficulty in speaking, swallowing, and breathing. |
| Aortic dissection | DOID:0080685 | aortic dissection | disease of anatomical entity | An aortic disease that is characterized by tearing of the intimal layer of the aorta resulting in separation of the layers of the aortic wall. |
| Aortic Dissection | DOID:0080685 | aortic dissection | disease of anatomical entity | An aortic disease that is characterized by tearing of the intimal layer of the aorta resulting in separation of the layers of the aortic wall. |
| Atherosclerosis | DOID:1936 | atherosclerosis | disease of anatomical entity | N/A |
| Atrial Fibrillation | DOID:0060224 | atrial fibrillation | disease of anatomical entity | A heart conduction disease that is characterized by uncoordinated electrical activity in the heart's upper chambers (the atria), which causes the heartbeat to become fast and irregular and has symptoms palpitations, weakness, fatigue, lightheadedness, dizziness, confusion, shortness of breath and chest pain. |
| Cardiomegaly | N/A | N/A | N/A | N/A |
| Cardiomyopathy, Dilated | DOID:12930 | dilated cardiomyopathy | disease of anatomical entity | An intrinsic cardiomyopathy that is characterized by an an enlarged heart and damage to the myocardium causing the heart to pump blood inefficiently. |
| Cardiomyopathy, Hypertrophic | DOID:11984 | hypertrophic cardiomyopathy | disease of anatomical entity | An intrinsic cardiomyopathy that is characterized by abnormal thickening (hypertrophy) of the heart without any obvious cause. |
| Carotid Artery Injuries | DOID:3407 | carotid artery disease | disease of anatomical entity | N/A |
| Cartilage Diseases | DOID:1222 | cartilage disease | disease of anatomical entity | A connective tissue disease that is located_in cartilage. |
| Depressive Disorder, Major | DOID:1470 | major depressive disorder | disease of mental health | A depressive disorder that is characterized by at least two weeks of loss of interest or pleasure in normally enjoyable activities or depressed mood along with additional cognitive or somatic impairments such as appetite or weight changes, sleep difficulties, psychomotor agitation or retardation, fatigue or loss of energy, diminished ability to think or concentrate, feelings of worthlessness or excessive guilt, and suicidality. |
| Diabetes Mellitus | DOID:9351 | diabetes mellitus | disease of metabolism//genetic disease | A glucose metabolism disease that is characterized by chronic hyperglycaemia with disturbances of carbohydrate, fat and protein metabolism resulting from defects in insulin secretion, insulin action, or both. |
| Diabetes Mellitus, Type 2 | DOID:9352 | type 2 diabetes mellitus | disease of metabolism//genetic disease | A diabetes mellitus that is characterized by high blood sugar, insulin resistance, and relative lack of insulin. |
| Diabetic Angiopathies | DOID:11713 | diabetic angiopathy | disease of anatomical entity | A peripheral vascular disease that is characterized by narrowing of the arteries as a complication arising from chronic diabetes. |
| Diabetic Foot | N/A | N/A | N/A | N/A |
| Diabetic Retinopathy | DOID:13207 | proliferative diabetic retinopathy | disease of anatomical entity//nervous system disease | N/A |
| Diffuse Intrinsic Pontine Glioma | DOID:0080880 | diffuse glioma, H3 G34 mutant | disease of cellular proliferation | A histone mutated tumor that has_material_basis_in mutations in codon 34 of the H3 histone family 3A protein. |
| Graves Ophthalmopathy | DOID:0081120 | Graves ophthalmopathy | disease of anatomical entity | An autoimmune disease of eyes, ear, nose and throat that is characterized by upper eyelid retraction, lid lag, swelling, redness, conjunctivitis, and bulging eyes. |
| Heart Defects, Congenital | DOID:1682 | congenital heart disease | physical disorder//disease of anatomical entity | N/A |
| Heart Failure | N/A | N/A | N/A | N/A |
| Hypertension | DOID:10763 | hypertension | disease of anatomical entity | An artery disease characterized by chronic elevated blood pressure in the arteries. |
| Intracranial Aneurysm | DOID:10941 | intracranial aneurysm | disease of anatomical entity//nervous system disease | N/A |
| Macular Degeneration | DOID:10871 | age related macular degeneration | disease of anatomical entity//genetic disease | A degeneration of macula and posterior pole that is characterized by a loss of vision in the center of the visual field (the macula) resulting from damage to the retina and resulting in blurring of the sharp central vision. |
| Mitochondrial Diseases | N/A | N/A | N/A | N/A |
| Moyamoya disease | DOID:13099 | Moyamoya disease | disease of anatomical entity//nervous system disease | A cerebral arterial disease characterized by constriction of certain arteries at the base of the brain. Blood flow is blocked by the constriction and also by blood clots. |
| Moyamoya Disease | DOID:13099 | Moyamoya disease | disease of anatomical entity//nervous system disease | A cerebral arterial disease characterized by constriction of certain arteries at the base of the brain. Blood flow is blocked by the constriction and also by blood clots. |
| Multiple Sclerosis, Relapsing-Remitting | DOID:2378 | relapsing-remitting multiple sclerosis | disease of anatomical entity//nervous system disease | A multiple sclerosis that is characterized by relapse (attacks of symptom flare-ups) followed by remission (periods of recovery). Symptoms may vary from mild to severe, and relapses and remissions may last for days or months. More than 80 percent of people who have MS begin with relapsing-remitting cycles. |
| Mycoplasma Infections | N/A | N/A | N/A | N/A |
| Myocardial Infarction | DOID:5844 | myocardial infarction | disease of anatomical entity | A coronary artery disease characterized by myocardial cell death (myocardial necrosis) due to prolonged ischaemia. |
| Myocardial Ischemia | N/A | N/A | N/A | N/A |
| Myocarditis | DOID:820 | myocarditis | disease of anatomical entity | An extrinsic cardiomyopathy that is characterized as an inflammation of the heart muscle. |
| Neurodegenerative Diseases | DOID:1289 | neurodegenerative disease | disease of anatomical entity | A central nervous system disease that results in the progressive deterioration of function or structure of neurons. |
| Obesity | DOID:9970 | obesity | disease of metabolism | An overnutrition that is characterized by excess body fat, traditionally defined as an elevated ratio of weight to height (specifically 30 kilograms per meter squared), has_material_basis_in a multifactorial etiology related to excess nutrition intake, decreased caloric utilization, and genetic susceptibility, and possibly medications and certain disorders of metabolism, endocrine function, and mental illness. |
| Osteoporosis | DOID:11476 | osteoporosis | disease of anatomical entity | A bone resorption disease characterized by decreased density of normally mineralized bone which results_in the thinning of bone tissue and decreased mechanical strength. |
| Ovarian Neoplasms | DOID:2394 | ovarian cancer | disease of anatomical entity//disease of cellular proliferation | A female reproductive organ cancer that is located_in the ovary. |
| Parkinson Disease | DOID:14330 | Parkinson's disease | disease of anatomical entity | A synucleinopathy that has_material_basis_in degeneration of the central nervous system that often impairs motor skills, speech, and other functions. |
| Polycystic Ovary Syndrome | DOID:11612 | polycystic ovary syndrome | disease of anatomical entity//reproductive system disease | An ovarian dysfunction that is characterized by hyperandrogenism, polycystic ovaries, hirsutism, oligomenorrhea or amenorrhea, anovulation and excessive body weight. |
| Reperfusion Injury | N/A | N/A | N/A | N/A |
| Rheumatic Heart Disease | DOID:0050827 | rheumatic heart disease | disease of anatomical entity | A heart valve disease that is characterized by repeated inflammation with fibrinous repair caused by an autoimmune reaction to Group A beta-hemolytic streptococci (GAS) that results in valvular damage. The cardinal anatomic changes of the valve include leaflet thickening, commissural fusion, and shortening and thickening of the tendinous cords. |
| Sleep Apnea, Obstructive | DOID:0050848 | obstructive sleep apnea | disease of mental health | A sleep apnea that is characterized by repeated collapse and obstruction of the upper airway during sleep, which results in reduced airflow (hypopnea) or complete airflow cessation (apnea), oxygen desaturation, and arousals from sleep. |
| Spinal Cord Injuries | N/A | N/A | N/A | N/A |
| Spotted Fever Group Rickettsiosis | DOID:11103 | rickettsialpox | disease by infectious agent | A spotted fever that has_material_basis_in Rickettsia akari, which is transmitted_by house mouse mite (Liponyssoides sanguineus) found on mice and other rodents. The infection has_symptom fever, has_symptom chills, has_symptom headache, has_symptom myalgia, and has_symptom papulovesicular rash. |
| Stroke | N/A | N/A | N/A | N/A |
| Thyroid Cancer, Papillary | DOID:3969 | thyroid gland papillary carcinoma | disease of anatomical entity//disease of cellular proliferation | A differentiated thyroid gland carcinoma that is characterized by the small mushroom shape of the tumor which has a stem attached to the epithelial layer and arises from the follicular cells of the thyroid gland. |
| Thyroid Neoplasms | DOID:3963 | thyroid gland carcinoma | disease of anatomical entity//disease of cellular proliferation | A thyroid gland cancer that has_material_basis_in epithelial cells. |
| Varicose Veins | DOID:799 | varicose veins | disease of anatomical entity | A vein disease that is characterized by swollen, twisted veins visible just under the surface of the skin. |
| Traumatic Brain | N/A | N/A | N/A | N/A |