The tsRNA and Disease Database (version 1.0)
| Disease | DO_ID | DO_Name | DO_Type | DO_Define |
|---|---|---|---|---|
| Alzheimer Disease | DOID:10652 | Alzheimer's disease | disease of anatomical entity | A tauopathy that is characterized by memory lapses, confusion, emotional instability and progressive loss of mental ability and results in progressive memory loss, impaired thinking, disorientation, and changes in personality and mood starting and leads in advanced cases to a profound decline in cognitive and physical functioning and is marked histologically by the degeneration of brain neurons especially in the cerebral cortex and by the presence of neurofibrillary tangles and plaques containing beta-amyloid. |
| Amyotrophic Lateral Sclerosis | DOID:332 | amyotrophic lateral sclerosis | disease of anatomical entity | A motor neuron disease that is characterized by muscle spasticity, rapidly progressive weakness due to muscle atrophy, difficulty in speaking, swallowing, and breathing. |
| Brain Injuries, Traumatic | DOID:0081292 | traumatic brain injury | disease of anatomical entity | A brain disease that is characterized by brain dysfunction caused by an outside force, usually a violent blow to the head. |
| Carotid Artery Injuries | DOID:3407 | carotid artery disease | disease of anatomical entity | N/A |
| Depressive Disorder, Major | DOID:1470 | major depressive disorder | disease of mental health | A depressive disorder that is characterized by at least two weeks of loss of interest or pleasure in normally enjoyable activities or depressed mood along with additional cognitive or somatic impairments such as appetite or weight changes, sleep difficulties, psychomotor agitation or retardation, fatigue or loss of energy, diminished ability to think or concentrate, feelings of worthlessness or excessive guilt, and suicidality. |
| Epilepsy | DOID:1826 | epilepsy | disease of anatomical entity | A brain disease that is characterized by the occurrance of at least two unprovoked seizures resulting from a persistent epileptogenic abnormality of the brain that is able to spontaneously generate paroxysmal activity and typically manifested by sudden brief episodes of altered or diminished consciousness, involuntary movements, or convulsions. |
| Fibrous Dysplasia of Bone | DOID:0080031 | fibrous dysplasia | disease of anatomical entity | A bone remodeling disease that results_in the destruction of normal bone and replacing it with fibrous bone tissue. |
| Mitochondrial Diseases | N/A | N/A | N/A | N/A |
| Multiple Sclerosis | DOID:2377 | multiple sclerosis | disease of anatomical entity//nervous system disease | A demyelinating disease that involves damage to the fatty myelin sheaths around the axons of the brain and spinal cord resulting in demyelination and scarring. |
| Neurodegenerative Diseases | DOID:1289 | neurodegenerative disease | disease of anatomical entity | A central nervous system disease that results in the progressive deterioration of function or structure of neurons. |
| Obesity | DOID:9970 | obesity | disease of metabolism | An overnutrition that is characterized by excess body fat, traditionally defined as an elevated ratio of weight to height (specifically 30 kilograms per meter squared), has_material_basis_in a multifactorial etiology related to excess nutrition intake, decreased caloric utilization, and genetic susceptibility, and possibly medications and certain disorders of metabolism, endocrine function, and mental illness. |
| Osteoarthritis | DOID:8398 | osteoarthritis | disease of anatomical entity | An arthritis that has_material_basis_in worn out cartilage located_in joint. |
| Osteoporosis | DOID:11476 | osteoporosis | disease of anatomical entity | A bone resorption disease characterized by decreased density of normally mineralized bone which results_in the thinning of bone tissue and decreased mechanical strength. |
| Parkinson Disease | DOID:14330 | Parkinson's disease | disease of anatomical entity | A synucleinopathy that has_material_basis_in degeneration of the central nervous system that often impairs motor skills, speech, and other functions. |
| Spinal Cord Injuries | N/A | N/A | N/A | N/A |