| | MeSH | Disease Ontology | | Disease ID: | D000544 | DOID:10652 | | Disease Name: | Alzheimer Disease | Alzheimer's disease | | Category: | MeSH | Disease Ontology | | Type: | Nervous System Diseases//Mental Disorders | disease of anatomical entity | | Define: | A degenerative disease of the BRAIN characterized by the insidious onset of DEMENTIA. Impairment of MEMORY, judgment, attention span, and problem solving skills are followed by severe APRAXIAS and a global loss of cognitive abilities. The condition primarily occurs after age 60, and is marked pathologically by severe cortical atrophy and the triad of SENILE PLAQUES; NEUROFIBRILLARY TANGLES; and NEUROPIL THREADS. (From Adams et al., Principles of Neurology, 6th ed, pp1049-57) | A tauopathy that is characterized by memory lapses, confusion, emotional instability and progressive loss of mental ability and results in progressive memory loss, impaired thinking, disorientation, and changes in personality and mood starting and leads in advanced cases to a profound decline in cognitive and physical functioning and is marked histologically by the degeneration of brain neurons especially in the cerebral cortex and by the presence of neurofibrillary tangles and plaques containing beta-amyloid. | | Alias: | Acute Confusional Senile Dementia//Alzheimer Dementia//Alzheimer Disease, Early Onset//Alzheimer Disease, Late Onset//Alzheimer Sclerosis//Alzheimer Syndrome//Alzheimer Type Senile Dementia//Alzheimer's Disease//Alzheimer's Disease, Focal Onset//Alzheimer's Diseases//Alzheimer-Type Dementia (ATD)//Dementia, Alzheimer Type//Dementia, Presenile//Dementia, Primary Senile Degenerative//Dementia, Senile//Early Onset Alzheimer Disease//Familial Alzheimer Disease (FAD)//Focal Onset Alzheimer's Disease//Late Onset Alzheimer Disease//Presenile Alzheimer Dementia//Primary Senile Degenerative Dementia//Senile Dementia, Acute Confusional//Senile Dementia, Alzheimer Type | Alzheimer disease//Alzheimers dementia |
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