Entry Detail


General Information

Database ID:TRD05565
Confidence:Very High
Contents:>> tsRNA Information
>> tsRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference



tsRNA Information

tsRNA Name:tsRNA-GlyGCC
tsRNA Type:N/A
Amino acid and Anticodon:N/A
Sequence:N/A
Related Target:SPIB
Predicted Target:N/A
External Links:
MINTbase ID:N/A
tRFdb ID:N/A



tsRNA Association Statistics

Total Associated Disease Number:1
More Information
Network:
(Display the first 15 nodes)



Disease Information

 MeSHDisease Ontology
Disease ID:D015179DOID:9256
Disease Name:Colorectal Neoplasmscolorectal cancer
Category:MeSHDisease Ontology
Type:Neoplasms//Digestive System Diseasesdisease of anatomical entity//disease of cellular proliferation
Define:Tumors or cancer of the COLON or the RECTUM or both. Risk factors for colorectal cancer include chronic ULCERATIVE COLITIS; FAMILIAL POLYPOSIS COLI; exposure to ASBESTOS; and irradiation of the CERVIX UTERI.A large intestine cancer that is located_in the colon and/or located_in the rectum.
Alias:Colorectal Cancer//Colorectal Carcinoma//Colorectal Tumors//Neoplasms, ColorectalN/A



Disease Association Statistics

Total Associated tsRNA Number:195
More Information
Network:
(Display the first 15 nodes)



Evidence Support

Strong Evidence:PCR//Western blot//FISH//Cell apoptosis assay//Luciferase reporter assay//Cell proliferation assay//Transwell assay
Weak Evidence:Sequencing



Reference

[1] PubMed ID:39153969
Disease Name:Colorectal Neoplasms
Tissue:Colon
Dysfunction Pattern:Up-Regulation
Validated Method:PCR//Western blot//FISH//Cell apoptosis assay//Luciferase reporter assay//Cell proliferation assay//Transwell assay//Sequencing
Description:The results showed that tsRNA-GlyGCC, tRF-28-Q99P9P9NH50E, tRF-32-J87383RPD9W1P, and tRF-27-OIQO4QPRJW3 were significantly upregulated in CRC tissues.
Comparision:Cancer VS Normal
Mechanism:In this study, we uncovered the feature of tsRNAs in human CRC tissues and confirmed a specific 5’ half tRNA, 5’tiRNA-Gly-GCC (tsRNA-GlyGCC), which is upregulated in CRC tissues and modulated by METTL1-mediated N(7)-methylguanosine tRNA modification. In vitro and in vivo experiments revealed the oncogenic role of tsRNA-GlyGCC in 5-FU drug resistance in CRC. Remarkably, our results showed that tsRNA-GlyGCC modulated the JAK1/STAT6 signaling pathway by targeting SPIB. Poly (β-amino esters) were synthesized to assist the delivery of 5-FU and tsRNA-GlyGCC inhibitor, which effectively inhibited tumor growth and enhanced CRC sensitive to 5-FU without obvious adverse effects in subcutaneous tumor.