tsRNADisease

Entry Detail

General Information

Database ID:	TRD05560
Confidence:	Very High
Contents:	>> tsRNA Information >> tsRNA Association Statistics >> Disease Information >> Disease Association Statistics >> Evidence Support >> Reference

tsRNA Information

tsRNA Name:

TsRNA-49-73-Glu-CTC

tsRNA Type:

N/A

Amino acid and Anticodon:

N/A

Sequence:

N/A

Related Target:

Predicted Target:

External Links:

MINTbase ID:	N/A
tRFdb ID:	N/A

tsRNA Association Statistics

Total Associated Disease Number:	1 More Information
Network: (Display the first 15 nodes)

Disease Information

	MeSH	Disease Ontology
Disease ID:	D002289	DOID:3908
Disease Name:	Carcinoma, Non-Small-Cell Lung	lung non-small cell carcinoma
Category:	MeSH	Disease Ontology
Type:	Neoplasms//Respiratory Tract Diseases	disease of anatomical entity//disease of cellular proliferation
Define:	A heterogeneous aggregate of at least three distinct histological types of lung cancer, including SQUAMOUS CELL CARCINOMA; ADENOCARCINOMA; and LARGE CELL CARCINOMA. They are dealt with collectively because of their shared treatment strategy.	A lung carcinoma that is characterized as any type of epithelial lung cancer other than small cell lung carcinoma.
Alias:	Carcinoma, Non-Small Cell Lung//Non-Small Cell Lung Cancer//Non-Small Cell Lung Carcinoma//Non-Small-Cell Lung Carcinoma//Nonsmall Cell Lung Cancer	Non-small cell lung cancer//non-small cell lung carcinoma//NSCLC

Disease Association Statistics

Total Associated tsRNA Number:	132 More Information
Network: (Display the first 15 nodes)

Evidence Support

Strong Evidence:	RT-PCR//Western blot//Transfection//Scratch wound healing assay
Weak Evidence:	High-throughput sequencing

Reference

[1] PubMed ID:	40153423
Disease Name:	Carcinoma, Non-Small-Cell Lung
Tissue:	Lung
Dysfunction Pattern:	Up-Regulation
Validated Method:	RT-PCR//Western blot//Transfection//Scratch wound healing assay//High-throughput sequencing
Description:	tsRNA-49-73-Glu-CTC is highly expressed in the serum of patients with NSCLC and demonstrates superior diagnostic value compared to commonly used tumor markers in clinical practice, such as Carcinoembryonic Antigen (CEA), Neuron-Specific Enolase (NSE), and Cytokeratin 19 Fragment (CYFRA).
Comparision:	Cancer VS Normal
Mechanism:	This study demonstrates that tsRNA-49:73-Glu-CTC is highly expressed in the serum of patients with NSCLC, indicating its potential as a novel non-invasive biomarker. Furthermore, it is implicated in the proliferation and migration of A549 cells, thereby opening new avenues for research into the pathogenesis of NSCLC.