Entry Detail


General Information

Database ID:TRD05548
Confidence:High
Contents:>> tsRNA Information
>> tsRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference



tsRNA Information

tsRNA Name:tsRNA-14783
tsRNA Type:N/A
Amino acid and Anticodon:N/A
Sequence:N/A
Related Target:N/A
Predicted Target:N/A
External Links:
MINTbase ID:N/A
tRFdb ID:N/A



tsRNA Association Statistics

Total Associated Disease Number:3
More Information
Network:
(Display the first 15 nodes)



Disease Information

 MeSHDisease Ontology
Disease ID:D007627N/A
Disease Name:KeloidN/A
Category:MeSHDisease Ontology
Type:Tissues//Skin and Connective Tissue Diseases//Pathological Conditions, Signs and SymptomsN/A
Define:A sharply elevated, irregularly shaped, progressively enlarging scar resulting from formation of excessive amounts of collagen in the dermis during connective tissue repair. It is differentiated from a hypertrophic scar (CICATRIX, HYPERTROPHIC) in that the former does not spread to surrounding tissues.N/A
Alias:N/AN/A



Disease Association Statistics

Total Associated tsRNA Number:38
More Information
Network:
(Display the first 15 nodes)



Evidence Support

Strong Evidence:RT-PCR
Weak Evidence:High-throughput sequencing



Reference

[1] PubMed ID:36368154
Disease Name:Keloid
Tissue:Macrophages
Dysfunction Pattern:Up-Regulation
Validated Method:RT-PCR//High-throughput sequencing
Description:tRNA derived fragment tsRNA-14783 promotes M2 polarization of macrophages in keloid.
Comparision:M2 VS M1
Mechanism:Consistent with the sequencing results, RT-qPCR verification confirmed that tsRNA-14777, tsRNA-14778 and tsRNA-14783 were up-regulated in M2 macrophages, compared with M1 macrophages (Fig. 4B).