tsRNADisease

Entry Detail

General Information

Database ID:	TRD05530
Confidence:	Very High
Contents:	>> tsRNA Information >> tsRNA Association Statistics >> Disease Information >> Disease Association Statistics >> Evidence Support >> Reference

tsRNA Information

tsRNA Name:

tsRNA-07804

tsRNA Type:

N/A

Amino acid and Anticodon:

N/A

Sequence:

N/A

Related Target:

Predicted Target:

External Links:

MINTbase ID:	N/A
tRFdb ID:	N/A

tsRNA Association Statistics

Total Associated Disease Number:	1 More Information
Network: (Display the first 15 nodes)

Disease Information

	MeSH	Disease Ontology
Disease ID:	D002289	DOID:3908
Disease Name:	Carcinoma, Non-Small-Cell Lung	lung non-small cell carcinoma
Category:	MeSH	Disease Ontology
Type:	Neoplasms//Respiratory Tract Diseases	disease of anatomical entity//disease of cellular proliferation
Define:	A heterogeneous aggregate of at least three distinct histological types of lung cancer, including SQUAMOUS CELL CARCINOMA; ADENOCARCINOMA; and LARGE CELL CARCINOMA. They are dealt with collectively because of their shared treatment strategy.	A lung carcinoma that is characterized as any type of epithelial lung cancer other than small cell lung carcinoma.
Alias:	Carcinoma, Non-Small Cell Lung//Non-Small Cell Lung Cancer//Non-Small Cell Lung Carcinoma//Non-Small-Cell Lung Carcinoma//Nonsmall Cell Lung Cancer	Non-small cell lung cancer//non-small cell lung carcinoma//NSCLC

Disease Association Statistics

Total Associated tsRNA Number:	132 More Information
Network: (Display the first 15 nodes)

Evidence Support

Strong Evidence:	PCR//Western blot
Weak Evidence:	High-throughput sequencing

Reference

[1] PubMed ID:	38289488
Disease Name:	Carcinoma, Non-Small-Cell Lung
Tissue:	H1299 cells
Dysfunction Pattern:	Up-Regulation
Validated Method:	PCR//Western blot//High-throughput sequencing
Description:	tsRNA-07804 was remarkably upregulated in vitamin D-treated H1299 cells.
Comparision:	Vitamin D-treated VS Control
Mechanism:	Functional experiments indicated that vitamin D led to mitochondrial dysfunction, repressed the proliferation, migration, invasion, and promoted apoptosis of H1299 cells via regulating tsRNA-07804. Mechanistically, tsRNA-07804 induced mitochondrial dysfunction and inhibited the malignancy of H1299 cells by suppressing CRKL expression. In vivo experiments showed that vitamin D inhibited the tumor growth in NSCLC by increasing tsRNA-07804 expression.