Entry Detail


General Information

Database ID:TRD05514
Confidence:Very High
Contents:>> tsRNA Information
>> tsRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference



tsRNA Information

tsRNA Name:tRHs
tsRNA Type:N/A
Amino acid and Anticodon:N/A
Sequence:N/A
Related Target:N/A
Predicted Target:N/A
External Links:
MINTbase ID:N/A
tRFdb ID:N/A



tsRNA Association Statistics

Total Associated Disease Number:1
More Information
Network:
(Display the first 15 nodes)



Disease Information

 MeSHDisease Ontology
Disease ID:D001249DOID:2841
Disease Name:Asthmaasthma
Category:MeSHDisease Ontology
Type:Respiratory Tract Diseases//Immune System Diseasesdisease of anatomical entity
Define:A form of bronchial disorder with three distinct components: airway hyper-responsiveness (RESPIRATORY HYPERSENSITIVITY), airway INFLAMMATION, and intermittent AIRWAY OBSTRUCTION. It is characterized by spasmodic contraction of airway smooth muscle, WHEEZING, and dyspnea (DYSPNEA, PAROXYSMAL).A bronchial disease that is characterized by chronic inflammation and narrowing of the airways, which is caused by a combination of environmental and genetic factors. The disease has_symptom recurring periods of wheezing (a whistling sound while breathing), has_symptom chest tightness, has_symptom shortness of breath, has_symptom mucus production and has_symptom coughing.
Alias:Asthma, Bronchial//Bronchial Asthmabronchial hyperreactivity//chronic obstructive asthma//chronic obstructive asthma with acute exacerbation//chronic obstructive asthma with status asthmaticus



Disease Association Statistics

Total Associated tsRNA Number:4
More Information
Network:
(Display the first 15 nodes)



Evidence Support

Strong Evidence:RT-PCR//Western Blot//Northern Blot//Cell Culture Assay
Weak Evidence:High-throughput sequencing



Reference

[1] PubMed ID:40442279
Disease Name:Asthma
Tissue:N/A
Dysfunction Pattern:N/A
Validated Method:RT-PCR//Western Blot//Northern Blot//Cell Culture Assay//High-throughput sequencing
Description:This study delved into the complex landscape of asthma, shedding light on previously unexplored pathways involving the production and secretion of tRNA fragments in the progression of this condition at both systemic and local levels. Our key findings reveal a significant upregulation of ANG expression in circulating leukocytes of severe asthma patients, alongside notable alterations in the extracellular levels of 5’-tRH Glu and 5’-tRH Gly in both blood and sputum samples from individuals with asthma.
Comparision:N/A
Mechanism:It has been observed that these patients exhibit an inadequate or dysfunctional response to environmental and physiological stressors, which can exacerbate inflammation and airway obstruction32. These disruptions in stress response mechanisms may trigger acute asthma exacerbations, escalating the severity of the disease and compromising the patient’s quality of life