Entry Detail


General Information

Database ID:TRD05509
Confidence:High
Contents:>> tsRNA Information
>> tsRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference



tsRNA Information

tsRNA Name:tRF18
tsRNA Type:N/A
Amino acid and Anticodon:N/A
Sequence:N/A
Related Target:KIF1B
Predicted Target:N/A
External Links:
MINTbase ID:N/A
tRFdb ID:N/A



tsRNA Association Statistics

Total Associated Disease Number:1
More Information
Network:
(Display the first 15 nodes)



Disease Information

 MeSHDisease Ontology
Disease ID:D000077273DOID:3969
Disease Name:Thyroid Cancer, Papillarythyroid gland papillary carcinoma
Category:MeSHDisease Ontology
Type:Neoplasms//Endocrine System Diseasesdisease of anatomical entity//disease of cellular proliferation
Define:An ADENOCARCINOMA that originates from follicular cells of the THYROID GLAND and accounts for the majority of THYROID CANCER cases. Cells exhibit enlarged, oval, or elongated morphologies with clear, round, nuclei. Fusions of RET, NTRK1, TPM3, and PCM1 genes are associated with this cancer.A differentiated thyroid gland carcinoma that is characterized by the small mushroom shape of the tumor which has a stem attached to the epithelial layer and arises from the follicular cells of the thyroid gland.
Alias:Familial Nonmedullary Thyroid Cancer//Nonmedullary Thyroid Carcinoma//Papillary Carcinoma Of Thyroid//Papillary Thyroid Carcinoma//Thyroid Carcinoma, PapillaryPapillary carcinoma of the Thyroid gland



Disease Association Statistics

Total Associated tsRNA Number:61
More Information
Network:
(Display the first 15 nodes)



Evidence Support

Strong Evidence:RT-PCR
Weak Evidence:N/A



Reference

[1] PubMed ID:35993942
Disease Name:Thyroid Cancer, Papillary
Tissue:Papillary Thyroid Carcinoma
Dysfunction Pattern:Up-Regulation
Validated Method:RT-PCR
Description:tRF-18 inhibition suppressed xenograft tumor growth. Mechanistically, tRF-18 was confirmed to target KIF1B and negatively regulate KIF1B expression in PTC cells. tRF-18 facilitates PTC cell proliferation and inhibits cell apoptosis by targeting.
Comparision:Cancer VS Normal
Mechanism:N/A