Entry Detail


General Information

Database ID:TRD05507
Confidence:High
Contents:>> tsRNA Information
>> tsRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference



tsRNA Information

tsRNA Name:tRF‐Glu‐TTC‐026
tsRNA Type:N/A
Amino acid and Anticodon:N/A
Sequence:N/A
Related Target:N/A
Predicted Target:N/A
External Links:
MINTbase ID:N/A
tRFdb ID:N/A



tsRNA Association Statistics

Total Associated Disease Number:1
More Information
Network:
(Display the first 15 nodes)



Disease Information

 MeSHDisease Ontology
Disease ID:D014376DOID:399
Disease Name:Tuberculosistuberculosis
Category:MeSHDisease Ontology
Type:Infectionsdisease by infectious agent
Define:Any of the infectious diseases of man and other animals caused by species of MYCOBACTERIUM TUBERCULOSIS.A primary bacterial infectious disease that is located_in lungs, located_in lymph nodes, located_in pericardium, located_in brain, located_in pleura or located_in gastrointestinal tract, has_material_basis_in Mycobacterium tuberculosis, which is transmitted_by droplets released into the air when an infected person coughs or sneezes.
Alias:Koch's Disease//Kochs Disease//Mycobacterium tuberculosis InfectionN/A



Disease Association Statistics

Total Associated tsRNA Number:5
More Information
Network:
(Display the first 15 nodes)



Evidence Support

Strong Evidence:RT-PCR
Weak Evidence:High-throughput sequencing



Reference

[1] PubMed ID:39043626
Disease Name:Tuberculosis
Tissue:peripheral blood mononuclear cells
Dysfunction Pattern:Up-Regulation
Validated Method:RT-PCR//High-throughput sequencing
Description:Tuberculosis patients exhibited markedly elevated levels of tRF‐Glu‐TTC‐026, tRF‐Ala‐AGC‐057, tRF‐Gly‐GCC‐012 and tRF‐Thr‐AGT‐019, the calculated The area under the curve (AUC) values range were from 0.52 To 0.90
Comparision:Disease VS Control
Mechanism:In the combined analysis, a logistic regression model with tRF‐Gly‐GCC‐012 and tRF‐Glu‐TTC‐026 resulted in a slightly higher AUC of 0.88 Compared with a single tRF‐Glu‐TTC‐026 (AUC = 0.87) And tRF‐Gly‐GCC‐012 (AUC = 0.71) In distinguishing TB from non‐TB . We found the potential use of tRF‐Glu‐TTC‐026 in distinguishing TB from LTBI, PN and HC (all AUC > 0.80). Amongst these tsRNAs, tRF‐Glu‐TTC‐026 was moderately correlated with lung injury severity. Based on the AUCs of the four confirmed tsRNAs in the discovery cohort and their correlations with the lung injury severity, we further evaluated the diagnostic value of tRF‐Glu‐TTC‐026 in TB.