tsRNADisease

Entry Detail

General Information

Database ID:	TRD05506
Confidence:	Very High
Contents:	>> tsRNA Information >> tsRNA Association Statistics >> Disease Information >> Disease Association Statistics >> Evidence Support >> Reference

tsRNA Information

tsRNA Name:

tRF‐1:28‐chrM.Ser‐TGA

tsRNA Type:

N/A

Amino acid and Anticodon:

N/A

Sequence:

N/A

Related Target:

Predicted Target:

External Links:

MINTbase ID:	N/A
tRFdb ID:	N/A

tsRNA Association Statistics

Total Associated Disease Number:	1 More Information
Network: (Display the first 15 nodes)

Disease Information

	MeSH	Disease Ontology
Disease ID:	D001749	DOID:4006
Disease Name:	Urinary Bladder Neoplasms	bladder urothelial carcinoma
Category:	MeSH	Disease Ontology
Type:	Neoplasms//Urogenital Diseases	disease of cellular proliferation//disease of anatomical entity
Define:	Tumors or cancer of the URINARY BLADDER.	A bladder carcinoma that has_material_basis_in transitional cells located_in the lining of the bladder.
Alias:	Bladder Cancer//Bladder Neoplasms//Bladder Tumors//Cancer of Bladder//Cancer of the Bladder//Malignant Tumor of Urinary Bladder//Neoplasms, Bladder//Urinary Bladder Cancer	bladder transitional cell carcinoma//transitional cell carcinoma of bladder//urinary bladder urothelial carcinoma//urothelial bladder carcinoma

Disease Association Statistics

Total Associated tsRNA Number:	41 More Information
Network: (Display the first 15 nodes)

Evidence Support

Strong Evidence:	PCR//Western blot//Transfection//Scratch wound healing assay//Cell proliferation assay
Weak Evidence:	tRF and tiRNA arrays

Reference

[1] PubMed ID:	39948752
Disease Name:	Urinary Bladder Neoplasms
Tissue:	serum
Dysfunction Pattern:	Up-Regulation
Validated Method:	PCR//Western blot//Transfection//Scratch wound healing assay//Cell proliferation assay//tRF and tiRNA arrays
Description:	Consistent with the results from the training set, tRF‐1:28‐chrM.Ser‐TGA and tiRNA‐1:34‐Glu‐CTC‐1‐M2 were significantly elevated in the bladder cancer group compared to the control group
Comparision:	Cancer VS Normal
Mechanism:	We also found that circulating tRF‐1:28‐chrM.Ser‐TGA and tiRNA‐1:34‐Glu‐CTC‐1‐M2 were specifically expressed and released by BLCA cells and were positively correlated with the degree of disease malignancy. In vitro and in vivo experiments revealed that the two tsRNAs exacerbated BLCA progression and played a role in promoting tumor lipid metabolism.