Entry Detail


General Information

Database ID:TRD05501
Confidence:High
Contents:>> tsRNA Information
>> tsRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference



tsRNA Information

tsRNA Name:tRF-T11
tsRNA Type:N/A
Amino acid and Anticodon:N/A
Sequence:N/A
Related Target:TRPA1
Predicted Target:N/A
External Links:
MINTbase ID:N/A
tRFdb ID:N/A



tsRNA Association Statistics

Total Associated Disease Number:3
More Information
Network:
(Display the first 15 nodes)



Disease Information

 MeSHDisease Ontology
Disease ID:D010051DOID:2394
Disease Name:Ovarian Neoplasmsovarian cancer
Category:MeSHDisease Ontology
Type:Neoplasms//Urogenital Diseases//Endocrine System Diseasesdisease of anatomical entity//disease of cellular proliferation
Define:Tumors or cancer of the OVARY. These neoplasms can be benign or malignant. They are classified according to the tissue of origin, such as the surface EPITHELIUM, the stromal endocrine cells, and the totipotent GERM CELLS. A female reproductive organ cancer that is located_in the ovary.
Alias:Cancer of Ovary//Cancer of the Ovary//Neoplasms, Ovarian//Ovarian Cancer//Ovary Cancer//Ovary Neoplasmsmalignant Ovarian tumor//malignant tumour of ovary//ovarian neoplasm//ovary neoplasm//primary ovarian cancer//tumor of the Ovary



Disease Association Statistics

Total Associated tsRNA Number:74
More Information
Network:
(Display the first 15 nodes)



Evidence Support

Strong Evidence:RIP
Weak Evidence:Data Mining



Reference

[1] PubMed ID:35317282
Disease Name:Ovarian Neoplasms
Tissue:Ovarian Cancer
Dysfunction Pattern:N/A
Validated Method:RIP//Data Mining
Description:An argonaute-RIP (AGO-RIP) assay demonstrated that tRF-T11 can interact with AGO2 to suppress TRPA1 via an RNAi pathway.
Comparision:N/A
Mechanism:In further in-depth Data Mining, it was revealed that tRF-T11 could target the 3′ UTR of TRPA1 mRNA to inhibit its expression. Besides, dual-luciferase reporter assay experiments were conducted to confirm its binding sites on TRPA1 mRNA. Finally, AGO-RIP assay was performed to demonstrate that tRF-T11 interacts with AGO2 to inhibit TRPA1 via the RNAi pathway in A2780 cells.