Entry Detail


General Information

Database ID:TRD05500
Confidence:Very High
Contents:>> tsRNA Information
>> tsRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference



tsRNA Information

tsRNA Name:tRF-Pro-CGG
tsRNA Type:N/A
Amino acid and Anticodon:N/A
Sequence:N/A
Related Target:CSF1
Predicted Target:N/A
External Links:
MINTbase ID:N/A
tRFdb ID:N/A



tsRNA Association Statistics

Total Associated Disease Number:3
More Information
Network:
(Display the first 15 nodes)



Disease Information

 MeSHDisease Ontology
Disease ID:D010190DOID:1793
Disease Name:Pancreatic Neoplasmspancreatic cancer
Category:MeSHDisease Ontology
Type:Neoplasms//Digestive System Diseases//Endocrine System Diseasesdisease of anatomical entity//disease of cellular proliferation
Define:Tumors or cancer of the PANCREAS. Depending on the types of ISLET CELLS present in the tumors, various hormones can be secreted: GLUCAGON from PANCREATIC ALPHA CELLS; INSULIN from PANCREATIC BETA CELLS; and SOMATOSTATIN from the SOMATOSTATIN-SECRETING CELLS. Most are malignant except the insulin-producing tumors (INSULINOMA).An endocrine gland cancer located_in the pancreas.
Alias:Cancer of Pancreas//Cancer of the Pancreas//Neoplasms, Pancreatic//Pancreas Cancer//Pancreas Neoplasms//Pancreatic CancerCa body of pancreas//Ca head of pancreas//Ca tail of pancreas//malignant neoplasm of body of pancreas//malignant neoplasm of head of pancreas//malignant neoplasm of tail of pancreas pancreas neoplasm [EXACT] pancreatic neoplasm [EXACT] pancreatic tumor [EXACT]



Disease Association Statistics

Total Associated tsRNA Number:112
More Information
Network:
(Display the first 15 nodes)



Evidence Support

Strong Evidence:PCR//Western blot//Cell apoptosis assay//Cell proliferation assay//Transwell assay//Luciferase reporter assay
Weak Evidence:Sequencing



Reference

[1] PubMed ID:40056302
Disease Name:Pancreatic Neoplasms
Tissue:Pancreas
Dysfunction Pattern:Down-Regulation
Validated Method:PCR//Western blot//Cell apoptosis assay//Cell proliferation assay//Transwell assay//Luciferase reporter assay//Sequencing
Description:TRF-Pro-CGG was significantly downregulated in PC tissues and cell lines compared to normal tissues and cells. Overexpression of tRF-Pro-CGG in SW1990 cells inhibited cell proliferation, clonality, migration, and invasion, while promoting apoptosis. Conversely, inhibition of tRF-Pro-CGG in PANC-1 cells had the opposite effects.
Comparision:Cancer VS Normal
Mechanism:Dual luciferase assays confirmed CSF1 as a direct target of tRF-Pro-CGG, and Western blot analysis showed that tRF-Pro-CGG negatively regulated CSF1 expression. Furthermore, tRF-Pro-CGG was found to modulate the PI3K-AKT signaling pathway, with downstream effects on key molecules such as AKT, P-AKT, and PTEN.