Entry Detail


General Information

Database ID:TRD05499
Confidence:Very High
Contents:>> tsRNA Information
>> tsRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference



tsRNA Information

tsRNA Name:tRF-Lys-CTT-010
tsRNA Type:N/A
Amino acid and Anticodon:N/A
Sequence:N/A
Related Target:SNRPA
Predicted Target:N/A
External Links:
MINTbase ID:N/A
tRFdb ID:N/A



tsRNA Association Statistics

Total Associated Disease Number:2
More Information
Network:
(Display the first 15 nodes)



Disease Information

 MeSHDisease Ontology
Disease ID:D001943DOID:1612
Disease Name:Breast Neoplasmsbreast cancer
Category:MeSHDisease Ontology
Type:Neoplasms//Skin and Connective Tissue Diseasesdisease of anatomical entity//disease of cellular proliferation
Define:Tumors or cancer of the human BREAST.A thoracic cancer that originates in the mammary gland.
Alias:Breast Cancer//Breast Carcinoma//Breast Tumors//Cancer of Breast//Cancer of the Breast//Human Mammary Carcinoma//Malignant Neoplasm of Breast//Malignant Tumor of Breast//Mammary Cancer//Mammary Carcinoma, Human//Mammary Neoplasm, Human//Mammary Neoplasms, Human//Neoplasms, Breast//Tumors, Breastbreast tumor//malignant neoplasm of breast//malignant tumor of the breast//mammary cancer//mammary neoplasm//mammary tumor//primary breast cancer



Disease Association Statistics

Total Associated tsRNA Number:549
More Information
Network:
(Display the first 15 nodes)



Evidence Support

Strong Evidence:PCR//Western blot//Transfection//Cell apoptosis assay//Cell proliferation assay//Pull down assay
Weak Evidence:High-throughput sequencing



Reference

[1] PubMed ID:40410734
Disease Name:Breast Neoplasms
Tissue:Breast
Dysfunction Pattern:Up-Regulation
Validated Method:PCR//Western blot//Transfection//Cell apoptosis assay//Cell proliferation assay//Pull down assay//High-throughput sequencing
Description:An expanded clinical sample size confirmed the expression patterns of four tRFs, consistent with sequencing results. Notably, tRFHis−GTG−006 and tRFLys−CTT−010 were significantly increased in tumor tissues, while tiRNA-Met (tRFMet−CAT−012) was downregulated; no significant difference was observed for tRFSer−TGA−001
Comparision:Cancer VS Normal
Mechanism:tiRNA-Met directly interacted with the RNA recognition motif 2 (RRM2) domain of small nuclear ribonucleoprotein A (SNRPA), promoting SNRPA protein degradation via the ubiquitin/proteasome pathway. This interaction enhanced the stability of Ran-binding protein 3-like (RANBP3L) mRNA, resulting in increased RANBP3L expression and subsequent inhibition of the mTORC1/RPS6 signaling pathway.