tsRNADisease

Entry Detail

General Information

Database ID:	TRD05494
Confidence:	Very High
Contents:	>> tsRNA Information >> tsRNA Association Statistics >> Disease Information >> Disease Association Statistics >> Evidence Support >> Reference

tsRNA Information

tsRNA Name:

tRF-Cys-GCA-029

tsRNA Type:

N/A

Amino acid and Anticodon:

N/A

Sequence:

N/A

Related Target:

Predicted Target:

External Links:

MINTbase ID:	N/A
tRFdb ID:	N/A

tsRNA Association Statistics

Total Associated Disease Number:	10 More Information
Network: (Display the first 15 nodes)

Disease Information

	MeSH	Disease Ontology
Disease ID:	D001943	DOID:1612
Disease Name:	Breast Neoplasms	breast cancer
Category:	MeSH	Disease Ontology
Type:	Neoplasms//Skin and Connective Tissue Diseases	disease of anatomical entity//disease of cellular proliferation
Define:	Tumors or cancer of the human BREAST.	A thoracic cancer that originates in the mammary gland.
Alias:	Breast Cancer//Breast Carcinoma//Breast Tumors//Cancer of Breast//Cancer of the Breast//Human Mammary Carcinoma//Malignant Neoplasm of Breast//Malignant Tumor of Breast//Mammary Cancer//Mammary Carcinoma, Human//Mammary Neoplasm, Human//Mammary Neoplasms, Human//Neoplasms, Breast//Tumors, Breast	breast tumor//malignant neoplasm of breast//malignant tumor of the breast//mammary cancer//mammary neoplasm//mammary tumor//primary breast cancer

Disease Association Statistics

Total Associated tsRNA Number:	549 More Information
Network: (Display the first 15 nodes)

Evidence Support

Strong Evidence:	PCR//Western blot//Transfection//Transwell assay
Weak Evidence:	Sequencing

Reference

[1] PubMed ID:	39039568
Disease Name:	Breast Neoplasms
Tissue:	Breast
Dysfunction Pattern:	Down-Regulation
Validated Method:	PCR//Western blot//Transfection//Transwell assay//Sequencing
Description:	We identified that tRF-Cys-GCA-029 was downregulated in BC-DM tissues and under hyperglycemia conditions in BC cells. Functionally, downregulation of tRF-Cys-GCA-029 promoted BC cell proliferation and migration in a glucose level-dependent manner. TRF-Cys-GCA-029 knockdown also enhanced glycolysis metabolism in BC cells, indicated by increasing lactate/pyruvate production and ECAR levels. Notably, injection of tRF-Cys-GCA-029 mimic significantly suppressed BC tumor growth in diabetic-mice.
Comparision:	Cancer VS Normal
Mechanism:	Mechanistically, tRF-Cys-GCA-029 regulated BC cell malignancy and glycolysis via interacting with PRKCG in two ways: binding to the coding sequence (CDS) of PRKCG mRNA to regulate its transcription and altering polysomal PRKCG mRNA expression to modify its translation.