Entry Detail


General Information

Database ID:TRD05425
Confidence:Very High
Contents:>> tsRNA Information
>> tsRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference



tsRNA Information

tsRNA Name:tRF-34-P4R8YP9LON4VHM
tsRNA Type:N/A
Amino acid and Anticodon:N/A
Sequence:GCATGGGTGGTTCAGTGGTAGAATTCTCGCCTGC
Related Target:DAB2IP
Predicted Target:FCGR2A//AATK//ZNF513//CNTLN//DPF1//TGM3//AL121899.2//F2RL2//LPAR1//TGIF2LX
External Links:
MINTbase ID:tRF-34-P4R8YP9LON4VHM
tRFdb ID:N/A

[1] gtRNAdb_ID:tRNA-Gly-GCC-1-1
Anticodon:GlyGCC
tRNA_number:trna35
Chromosome:1
Strand:+
Coordinate:Start Site(bp): 161413094        End Site(bp): 161413127

[2] gtRNAdb_ID:tRNA-Gly-GCC-1-2
Anticodon:GlyGCC
tRNA_number:trna37
Chromosome:1
Strand:+
Coordinate:Start Site(bp): 161420467        End Site(bp): 161420500

[3] gtRNAdb_ID:tRNA-Gly-GCC-1-3
Anticodon:GlyGCC
tRNA_number:trna39
Chromosome:1
Strand:+
Coordinate:Start Site(bp): 161427898        End Site(bp): 161427931

[4] gtRNAdb_ID:tRNA-Gly-GCC-1-4
Anticodon:GlyGCC
tRNA_number:trna41
Chromosome:1
Strand:+
Coordinate:Start Site(bp): 161435258        End Site(bp): 161435291

[5] gtRNAdb_ID:tRNA-Gly-GCC-1-5
Anticodon:GlyGCC
tRNA_number:trna2
Chromosome:21
Strand:-
Coordinate:Start Site(bp): 18827144        End Site(bp): 18827177



tsRNA Association Statistics

Total Associated Disease Number:1
More Information
Network:
(Display the first 15 nodes)



Disease Information

 MeSHDisease Ontology
Disease ID:D006528DOID:684
Disease Name:Carcinoma, Hepatocellularhepatocellular carcinoma
Category:MeSHDisease Ontology
Type:Neoplasms//Digestive System Diseasesdisease of anatomical entity//disease of cellular proliferation
Define:A primary malignant neoplasm of epithelial liver cells. It ranges from a well-differentiated tumor with EPITHELIAL CELLS indistinguishable from normal HEPATOCYTES to a poorly differentiated neoplasm. The cells may be uniform or markedly pleomorphic, or form GIANT CELLS. Several classification schemes have been suggested.A liver carcinoma that has_material_basis_in undifferentiated hepatocytes and located_in the liver.
Alias:Hepatocellular Carcinoma//Hepatoma//Liver Cancer, Adult//Liver Cell Carcinoma//Liver Cell Carcinoma, AdultHepatoma



Disease Association Statistics

Total Associated tsRNA Number:61
More Information
Network:
(Display the first 15 nodes)



Evidence Support

Strong Evidence:PCR//Western blot//Transfection//EDU//Cell proliferation assay//Cell cycle assay//Transwell assay
Weak Evidence:High-throughput sequencing



Reference

[1] PubMed ID:40263693
Disease Name:Carcinoma, Hepatocellular
Tissue:Liver
Dysfunction Pattern:Up-Regulation
Validated Method:PCR//Western blot//Transfection//EDU//Cell proliferation assay//Cell cycle assay//Transwell assay//High-throughput sequencing
Description:We performed CCK8, colony formation assay, EdU, cell cycle analysis, transwell assay, and tube formation assay to verify that tRF‐34‐P4R8YP9LON4VHM could enhance HCC proliferation, migration, invasion, and tumour cell‐induced angiogenesis in vitro and in vivo.
Comparision:Cancer VS Normal
Mechanism:TRF‐34‐P4R8YP9LON4VHM could downregulate DAB2IP expression by directly targeting its 3'‐UTR, consequently activating the MEK/ERK signalling pathway and promoting the secretion of VEGFA from HCC cells into the supernatant. In conclusion, our research indicated that tRF‐34‐P4R8YP9LON4VHM might act as a crucial player in molecular mechanisms and provide novel treatment strategies for HCC patients.