Entry Detail


General Information

Database ID:TRD05414
Confidence:High
Contents:>> tsRNA Information
>> tsRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference



tsRNA Information

tsRNA Name:tRF-33-RZYQHQ9M739P0J
tsRNA Type:N/A
Amino acid and Anticodon:N/A
Sequence:GGTTTTTCATATCATTGGTCGTGGTTGTAGTCC
Related Target:N/A
Predicted Target:ZBTB39//NOP16//TMEFF1//MSANTD3-TMEFF1//ELOF1//ARHGAP42//STAB1//ANKRD54//LTN1//CAND2
External Links:
MINTbase ID:tRF-33-RZYQHQ9M739P0J
tRFdb ID:N/A

[1] gtRNAdb_ID:-
Anticodon:GluTTC
tRNA_number:trnaMT
Chromosome:MT
Strand:-
Coordinate:Start Site(bp): 14685        End Site(bp): 14717

[2] gtRNAdb_ID:-
Anticodon:GluTTC
tRNA_number:trnalookalike8
Chromosome:5
Strand:-
Coordinate:Start Site(bp): 93905183        End Site(bp): 93905215



tsRNA Association Statistics

Total Associated Disease Number:2
More Information
Network:
(Display the first 15 nodes)



Disease Information

 MeSHDisease Ontology
Disease ID:D006528DOID:684
Disease Name:Carcinoma, Hepatocellularhepatocellular carcinoma
Category:MeSHDisease Ontology
Type:Neoplasms//Digestive System Diseasesdisease of anatomical entity//disease of cellular proliferation
Define:A primary malignant neoplasm of epithelial liver cells. It ranges from a well-differentiated tumor with EPITHELIAL CELLS indistinguishable from normal HEPATOCYTES to a poorly differentiated neoplasm. The cells may be uniform or markedly pleomorphic, or form GIANT CELLS. Several classification schemes have been suggested.A liver carcinoma that has_material_basis_in undifferentiated hepatocytes and located_in the liver.
Alias:Hepatocellular Carcinoma//Hepatoma//Liver Cancer, Adult//Liver Cell Carcinoma//Liver Cell Carcinoma, AdultHepatoma



Disease Association Statistics

Total Associated tsRNA Number:61
More Information
Network:
(Display the first 15 nodes)



Evidence Support

Strong Evidence:PCR//Western blot
Weak Evidence:High-throughput sequencing



Reference

[1] PubMed ID:38707447
Disease Name:Carcinoma, Hepatocellular
Tissue:Liver
Dysfunction Pattern:Up-Regulation
Validated Method:PCR//Western blot//High-throughput sequencing
Description:QRT-PCR analysis of the cell lines showed that tRF-33-RZYQHQ9M739P0J expression levels were significantly higher in most HCC cell lines than QSG-7701. The above results indicated that tRF-33-RZYQHQ9M739P0J may be valuable in HCC diagnosis, so it was selected as a potential molecule for further study.
Comparision:Cancer VS Normal
Mechanism:TRF-33-RZYQHQ9M739P0J was highly expressed in HCC tissues and sera, and its expression was correlated with metastasis, TNM stage, BCLC stage, and vein invasion. Expression of tRF-33-RZYQHQ9M739P0J were decreased after surgery in patients with HCC. High serum tRF-33-RZYQHQ9M739P0J levels are associated with low survival rates, and they can predict survival times in patients with HCC according to the Kaplan-Meier analysis.