Entry Detail


General Information

Database ID:TRD05413
Confidence:Very High
Contents:>> tsRNA Information
>> tsRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference



tsRNA Information

tsRNA Name:tRF-33-P4R8YP9LON4VDP
tsRNA Type:N/A
Amino acid and Anticodon:N/A
Sequence:GCATGGGTGGTTCAGTGGTAGAATTCTCGCCTG
Related Target:AGO2
Predicted Target:FCGR2A//B4GALNT4//ZNF513//CNTLN//TGIF2LX//TGIF2LY//DPF1//LPAR1//AATK//F2RL2
External Links:
MINTbase ID:tRF-33-P4R8YP9LON4VDP
tRFdb ID:N/A

[1] gtRNAdb_ID:tRNA-Gly-GCC-1-1
Anticodon:GlyGCC
tRNA_number:trna35
Chromosome:1
Strand:+
Coordinate:Start Site(bp): 161413094        End Site(bp): 161413126

[2] gtRNAdb_ID:tRNA-Gly-GCC-1-2
Anticodon:GlyGCC
tRNA_number:trna37
Chromosome:1
Strand:+
Coordinate:Start Site(bp): 161420467        End Site(bp): 161420499

[3] gtRNAdb_ID:tRNA-Gly-GCC-1-3
Anticodon:GlyGCC
tRNA_number:trna39
Chromosome:1
Strand:+
Coordinate:Start Site(bp): 161427898        End Site(bp): 161427930

[4] gtRNAdb_ID:tRNA-Gly-GCC-1-4
Anticodon:GlyGCC
tRNA_number:trna41
Chromosome:1
Strand:+
Coordinate:Start Site(bp): 161435258        End Site(bp): 161435290

[5] gtRNAdb_ID:tRNA-Gly-GCC-1-5
Anticodon:GlyGCC
tRNA_number:trna2
Chromosome:21
Strand:-
Coordinate:Start Site(bp): 18827145        End Site(bp): 18827177



tsRNA Association Statistics

Total Associated Disease Number:8
More Information
Network:
(Display the first 15 nodes)



Disease Information

 MeSHDisease Ontology
Disease ID:D013274 DOID:10534
Disease Name:Stomach Neoplasmsstomach cancer
Category:MeSHDisease Ontology
Type:Neoplasms//Digestive System Diseasesdisease of anatomical entity//disease of cellular proliferation
Define:Tumors or cancer of the STOMACH.A gastrointestinal system cancer that is located_in the stomach.
Alias:Cancer of Stomach//Cancer of the Stomach//Gastric Cancer//Gastric Cancer, Familial Diffuse//Gastric Neoplasms//Neoplasms, Gastric//Neoplasms, Stomach//Stomach Cancergastric cancer//gastric neoplasm



Disease Association Statistics

Total Associated tsRNA Number:79
More Information
Network:
(Display the first 15 nodes)



Evidence Support

Strong Evidence:PCR//Western blot/Cell apoptosis assay//Luciferase reporter assay//Cell proliferation assay//Transwell assay
Weak Evidence:Sequencing



Reference

[1] PubMed ID:38783100
Disease Name:Stomach Neoplasms
Tissue:Stomach
Dysfunction Pattern:Up-Regulation
Validated Method:PCR//Western blot/Cell apoptosis assay//Luciferase reporter assay//Cell proliferation assay//Transwell assay//Sequencing
Description:The results showed that the expression of tRF-33 exhibited a gradual modification from normal control samples to gastritis tissues, early and latent stage of gastric cancer tissues. Consequently, tRF-33 holds significant potential as a predictive and diagnostic biomarker for gastric malignancy.
Comparision:Cancer VS Normal
Mechanism:Over-expression of tRF-33 inhibited gastric cancer cell progression and metastatic viability, and induced cell apoptosis. Tumorigenicity in nude mice showed the suppressive characteristics of tRF-33. Mechanistic investigation revealed that tRF-33 exerted silencing on STAT3 mRNA via binding to AGO2.