Entry Detail


General Information

Database ID:TRD05412
Confidence:Very High
Contents:>> tsRNA Information
>> tsRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference



tsRNA Information

tsRNA Name:tRF-33-MEF91SS2PMFI0Q
tsRNA Type:N/A
Amino acid and Anticodon:N/A
Sequence:CGGATAGCTCAGTCGGTAGAGCATCAGACTTTT
Related Target:IGF1
Predicted Target:PAQR3//AWAT1//WIPI2//NRIP2//PLPPR1//SMIM7//AC008764.4//MRGPRD//USP54//ICAM4
External Links:
MINTbase ID:tRF-33-MEF91SS2PMFI0Q
tRFdb ID:N/A

[1] gtRNAdb_ID:tRNA-Lys-TTT-5-1
Anticodon:LysTTT
tRNA_number:trna5
Chromosome:11
Strand:+
Coordinate:Start Site(bp): 59323905        End Site(bp): 59323937

[2] gtRNAdb_ID:tRNA-Lys-TTT-3-1
Anticodon:LysTTT
tRNA_number:trna54
Chromosome:1
Strand:+
Coordinate:Start Site(bp): 204475658        End Site(bp): 204475690

[3] gtRNAdb_ID:tRNA-Lys-TTT-3-2
Anticodon:LysTTT
tRNA_number:trna62
Chromosome:1
Strand:-
Coordinate:Start Site(bp): 204476195        End Site(bp): 204476227

[4] gtRNAdb_ID:tRNA-Lys-TTT-3-4
Anticodon:LysTTT
tRNA_number:trna14
Chromosome:11
Strand:-
Coordinate:Start Site(bp): 59327845        End Site(bp): 59327877

[5] gtRNAdb_ID:tRNA-Lys-TTT-3-5
Anticodon:LysTTT
tRNA_number:trna2
Chromosome:17
Strand:+
Coordinate:Start Site(bp): 8022476        End Site(bp): 8022508

[6] gtRNAdb_ID:tRNA-Lys-TTT-3-3
Anticodon:LysTTT
tRNA_number:trna76
Chromosome:6
Strand:+
Coordinate:Start Site(bp): 28918809        End Site(bp): 28918841



tsRNA Association Statistics

Total Associated Disease Number:1
More Information
Network:
(Display the first 15 nodes)



Disease Information

 MeSHDisease Ontology
Disease ID:D001943DOID:1612
Disease Name:Breast Neoplasmsbreast cancer
Category:MeSHDisease Ontology
Type:Neoplasms//Skin and Connective Tissue Diseasesdisease of anatomical entity//disease of cellular proliferation
Define:Tumors or cancer of the human BREAST.A thoracic cancer that originates in the mammary gland.
Alias:Breast Cancer//Breast Carcinoma//Breast Tumors//Cancer of Breast//Cancer of the Breast//Human Mammary Carcinoma//Malignant Neoplasm of Breast//Malignant Tumor of Breast//Mammary Cancer//Mammary Carcinoma, Human//Mammary Neoplasm, Human//Mammary Neoplasms, Human//Neoplasms, Breast//Tumors, Breastbreast tumor//malignant neoplasm of breast//malignant tumor of the breast//mammary cancer//mammary neoplasm//mammary tumor//primary breast cancer



Disease Association Statistics

Total Associated tsRNA Number:549
More Information
Network:
(Display the first 15 nodes)



Evidence Support

Strong Evidence:PCR//Western blot//Transfection//Transwell assay
Weak Evidence:Sequencing



Reference

[1] PubMed ID:39792150
Disease Name:Breast Neoplasms
Tissue:Breast
Dysfunction Pattern:Up-Regulation
Validated Method:PCR//Western blot//Transfection//Transwell assay//Sequencing
Description:In this study, we identified differential expression of tRNA fragments in HER2-negative BC tissues compared with adjacent normal tissues, observing significant upregulation of an i-tRF type tRF-33-MEF91SS2PMFI0Q (tRF-33) in the tumor tissue. We also found that tRF-33 promoted tumorigenesis in BC cells.
Comparision:Cancer VS Normal
Mechanism:We also found that tRF-33 promoted tumorigenesis in BC cells. We demonstrated for the first time that IGF1 was a target gene of tRF-33 and also showed that the tRF-33/IGF1 axis impaired mitochondrial dynamics, thus affecting mitochondrial homeostasis and promoting HER2-negative BC progression.