Entry Detail


General Information

Database ID:TRD05399
Confidence:High
Contents:>> tsRNA Information
>> tsRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference



tsRNA Information

tsRNA Name:tRF-31-87R8WP9N1EWJ0
tsRNA Type:N/A
Amino acid and Anticodon:N/A
Sequence:TCCCTGGTGGTCTAGTGGTTAGGATTCGGCGC
Related Target:N/A
Predicted Target:TFCP2L1//EME2//SLC25A48//TMEM92//RFTN1//SLC25A6//PAQR4//CCDC159//PDE12//ALKBH2
External Links:
MINTbase ID:tRF-32-87R8WP9N1EWJM
tRFdb ID:N/A

[1] gtRNAdb_ID:tRNA-Glu-CTC-2-1
Anticodon:GluCTC
tRNA_number:trna59
Chromosome:1
Strand:+
Coordinate:Start Site(bp): 249168447        End Site(bp): 249168478

[2] gtRNAdb_ID:tRNA-Glu-CTC-1-1
Anticodon:GluCTC
tRNA_number:trna116
Chromosome:1
Strand:-
Coordinate:Start Site(bp): 145399273        End Site(bp): 145399304

[3] gtRNAdb_ID:tRNA-Glu-CTC-1-5
Anticodon:GluCTC
tRNA_number:trna71
Chromosome:1
Strand:-
Coordinate:Start Site(bp): 161439229        End Site(bp): 161439260

[4] gtRNAdb_ID:tRNA-Glu-CTC-1-4
Anticodon:GluCTC
tRNA_number:trna74
Chromosome:1
Strand:-
Coordinate:Start Site(bp): 161431849        End Site(bp): 161431880

[5] gtRNAdb_ID:tRNA-Glu-CTC-1-3
Anticodon:GluCTC
tRNA_number:trna77
Chromosome:1
Strand:-
Coordinate:Start Site(bp): 161424438        End Site(bp): 161424469

[6] gtRNAdb_ID:tRNA-Glu-CTC-1-2
Anticodon:GluCTC
tRNA_number:trna80
Chromosome:1
Strand:-
Coordinate:Start Site(bp): 161417058        End Site(bp): 161417089

[7] gtRNAdb_ID:tRNA-Glu-CTC-1-6
Anticodon:GluCTC
tRNA_number:trna77
Chromosome:6
Strand:+
Coordinate:Start Site(bp): 28949976        End Site(bp): 28950007

[8] gtRNAdb_ID:tRNA-Glu-CTC-1-7
Anticodon:GluCTC
tRNA_number:trna87
Chromosome:6
Strand:-
Coordinate:Start Site(bp): 126101433        End Site(bp): 126101464



tsRNA Association Statistics

Total Associated Disease Number:4
More Information
Network:
(Display the first 15 nodes)



Disease Information

 MeSHDisease Ontology
Disease ID:D002289DOID:3908
Disease Name:Carcinoma, Non-Small-Cell Lunglung non-small cell carcinoma
Category:MeSHDisease Ontology
Type:Neoplasms//Respiratory Tract Diseasesdisease of anatomical entity//disease of cellular proliferation
Define:A heterogeneous aggregate of at least three distinct histological types of lung cancer, including SQUAMOUS CELL CARCINOMA; ADENOCARCINOMA; and LARGE CELL CARCINOMA. They are dealt with collectively because of their shared treatment strategy.A lung carcinoma that is characterized as any type of epithelial lung cancer other than small cell lung carcinoma.
Alias:Carcinoma, Non-Small Cell Lung//Non-Small Cell Lung Cancer//Non-Small Cell Lung Carcinoma//Non-Small-Cell Lung Carcinoma//Nonsmall Cell Lung CancerNon-small cell lung cancer//non-small cell lung carcinoma//NSCLC



Disease Association Statistics

Total Associated tsRNA Number:132
More Information
Network:
(Display the first 15 nodes)



Evidence Support

Strong Evidence:RT-PCR
Weak Evidence:tRF and tiRNA arrays



Reference

[1] PubMed ID:39145073
Disease Name:Carcinoma, Non-Small-Cell Lung
Tissue:serum
Dysfunction Pattern:Up-Regulation
Validated Method:RT-PCR//tRF and tiRNA arrays
Description:Eleven up-regulated tRFs/tiRNAs and 18 down-regulated tRFs/tiRNAs were determined. Levels of tRF-31-87R8WP9N1EWJ0 and tRF-31-79MP9P9NH57SD were significantly higher in NSCLC serum samples than those of healthy controls
Comparision:Cancer VS Normal
Mechanism:We found that tRF-31-87R8WP9N1EWJ0 and tRF-31-79MP9P9NH57SD exhibited significantly higher levels in NSCLC serum samples compared with healthy controls. The positive results suggest that tRF-31-87R8WP9N1EWJ0 and tRF-31-79MP9P9NH57SD may be new potential biomarkers for NSCLC. Tissue or blood expression level in larger samples of NSCLC patients with different stages and healthy people could further help determine the diagnostic and prognostic value of the two tRFs.