tsRNADisease

Entry Detail

General Information

Database ID:	TRD05394
Confidence:	Very High
Contents:	>> tsRNA Information >> tsRNA Association Statistics >> Disease Information >> Disease Association Statistics >> Evidence Support >> Reference

tsRNA Information

tsRNA Name:

tRF-3019A

tsRNA Type:

N/A

Amino acid and Anticodon:

N/A

Sequence:

N/A

Related Target:

Predicted Target:

External Links:

MINTbase ID:	N/A
tRFdb ID:	N/A

tsRNA Association Statistics

Total Associated Disease Number:	3 More Information
Network: (Display the first 15 nodes)

Disease Information

	MeSH	Disease Ontology
Disease ID:	D003110	DOID:219
Disease Name:	Colonic Neoplasms	colon cancer
Category:	MeSH	Disease Ontology
Type:	Neoplasms//Digestive System Diseases	disease of anatomical entity//disease of cellular proliferation
Define:	Tumors or cancer of the COLON.	A colorectal cancer that is located_in the colon.
Alias:	Cancer of Colon//Cancer of the Colon//Colon Adenocarcinoma//Colon Cancer//Colon Neoplasms//Colonic Cancer//Neoplasms, Colonic	N/A

Disease Association Statistics

Total Associated tsRNA Number:	91 More Information
Network: (Display the first 15 nodes)

Evidence Support

Strong Evidence:	PCR//Western blot//Transfection//Transwell assay
Weak Evidence:	Sequencing

Reference

[1] PubMed ID:	40268078
Disease Name:	Colonic Neoplasms
Tissue:	Colon
Dysfunction Pattern:	Up-Regulation
Validated Method:	PCR//Western blot//Transfection//Transwell assay//Sequencing
Description:	In colon cancer tissues and cells, tRF-3019 A was overexpressed, and by triggering autophagy, it may encourage cell division, migration, and invasion.
Comparision:	Cancer VS Normal
Mechanism:	From a mechanistic perspective, tRF-3019 A competitively bound to the STAU1 protein with BECN1 mRNA, thereby enhancing the stable expression of the autophagy-related protein BECN1. In the model of xenograft tumor mice with knockdown of STAU1, blocking tRF-3019 A led to a substantial decrease in the pace of tumor development, a reduction in the expression of EMT-related proteins and autophagy, and an inhibition of autophagy.