Entry Detail


General Information

Database ID:TRD05386
Confidence:High
Contents:>> tsRNA Information
>> tsRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference



tsRNA Information

tsRNA Name:tRF-30
tsRNA Type:N/A
Amino acid and Anticodon:N/A
Sequence:N/A
Related Target:TRIB3
Predicted Target:N/A
External Links:
MINTbase ID:N/A
tRFdb ID:N/A



tsRNA Association Statistics

Total Associated Disease Number:1
More Information
Network:
(Display the first 15 nodes)



Disease Information

 MeSHDisease Ontology
Disease ID:D003930DOID:13207
Disease Name:Diabetic Retinopathyproliferative diabetic retinopathy
Category:MeSHDisease Ontology
Type:Eye Diseases//Cardiovascular Diseases//Endocrine System Diseasesdisease of anatomical entity//nervous system disease
Define:Disease of the RETINA as a complication of DIABETES MELLITUS. It is characterized by the progressive microvascular complications, such as ANEURYSM, interretinal EDEMA, and intraocular PATHOLOGIC NEOVASCULARIZATION.N/A
Alias:N/APDR



Disease Association Statistics

Total Associated tsRNA Number:86
More Information
Network:
(Display the first 15 nodes)



Evidence Support

Strong Evidence:RT-PCR
Weak Evidence:High-throughput sequencing



Reference

[1] PubMed ID:39001618
Disease Name:Diabetic Retinopathy
Tissue:Retina
Dysfunction Pattern:Up-Regulation
Validated Method:RT-PCR//High-throughput sequencing
Description:Conversely, inhibition of tRF-30 expression suppressed the formation of abnormal neovascularization in the retina in vivo, while reducing the proliferation and migration activity of retinal vascular endothelial cells in vitro
Comparision:Disease VS Control
Mechanism:We also found that tRF-30 modulates retinal neovascularization through the tRF-30/TRIB3/signal transducer and activated transcription 3 signaling pathway.