Entry Detail



General Information

Database ID:TRD05357
Confidence:Very High
Contents:>> tsRNA Information
>> tsRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference



tsRNA Information

tsRNA Name:tRF-18-8R6546D2
tsRNA Type:N/A
Amino acid and Anticodon:N/A
Sequence:TCCCCGGCACCTCCACCA
Related Target:ASCL2
Predicted Target:SEC14L1//RAB43//ISY1-RAB43//FAM171A2//SMTN//RIC3//RETREG3//EGLN3//DCHS1//PLXNB1
External Links:
MINTbase ID:tRF-18-8R6546D2
tRFdb ID:N/A

[1] gtRNAdb_ID:tRNA-Ala-AGC-3-1
Anticodon:AlaAGC
tRNA_number:trna65
Chromosome:6
Strand:+
Coordinate:Start Site(bp): 28574990        End Site(bp): 28575004+3

[2] gtRNAdb_ID:tRNA-Ala-AGC-2-2
Anticodon:AlaAGC
tRNA_number:trna101
Chromosome:6
Strand:-
Coordinate:Start Site(bp): 28831462-3        End Site(bp): 28831476

[3] gtRNAdb_ID:tRNA-Ala-AGC-2-1
Anticodon:AlaAGC
tRNA_number:trna102
Chromosome:6
Strand:-
Coordinate:Start Site(bp): 28806221-3        End Site(bp): 28806235

[4] gtRNAdb_ID:tRNA-Ala-TGC-6-1
Anticodon:AlaTGC
tRNA_number:trna113
Chromosome:6
Strand:-
Coordinate:Start Site(bp): 28726141-3        End Site(bp): 28726155

[5] gtRNAdb_ID:tRNA-Ala-TGC-1-1
Anticodon:AlaTGC
tRNA_number:trna110
Chromosome:6
Strand:-
Coordinate:Start Site(bp): 28757547-3        End Site(bp): 28757561



tsRNA Association Statistics

Total Associated Disease Number:3
More Information
Network:
(Display the first 15 nodes)



Disease Information

 MeSHDisease Ontology
Disease ID:D010190DOID:1793
Disease Name:Pancreatic Neoplasmspancreatic cancer
Category:MeSHDisease Ontology
Type:Neoplasms//Digestive System Diseases//Endocrine System Diseasesdisease of anatomical entity//disease of cellular proliferation
Define:Tumors or cancer of the PANCREAS. Depending on the types of ISLET CELLS present in the tumors, various hormones can be secreted: GLUCAGON from PANCREATIC ALPHA CELLS; INSULIN from PANCREATIC BETA CELLS; and SOMATOSTATIN from the SOMATOSTATIN-SECRETING CELLS. Most are malignant except the insulin-producing tumors (INSULINOMA).An endocrine gland cancer located_in the pancreas.
Alias:Cancer of Pancreas//Cancer of the Pancreas//Neoplasms, Pancreatic//Pancreas Cancer//Pancreas Neoplasms//Pancreatic CancerCa body of pancreas//Ca head of pancreas//Ca tail of pancreas//malignant neoplasm of body of pancreas//malignant neoplasm of head of pancreas//malignant neoplasm of tail of pancreas pancreas neoplasm [EXACT] pancreatic neoplasm [EXACT] pancreatic tumor [EXACT]



Disease Association Statistics

Total Associated tsRNA Number:112
More Information
Network:
(Display the first 15 nodes)



Evidence Support

Strong Evidence:PCR//Western blot//FISH//Cell apoptosis assay//Luciferase reporter assay//Cell proliferation assay//Transwell assay//RIP
Weak Evidence:Sequencing



Reference

[1] PubMed ID:38955307
Disease Name:Pancreatic Neoplasms
Tissue:Pancreas
Dysfunction Pattern:Up-Regulation
Validated Method:PCR//Western blot//FISH//Cell apoptosis assay//Luciferase reporter assay//Cell proliferation assay//Transwell assay//RIP//Sequencing
Description:He results show that tRF-18-8R6546D2 is correlated with PAAD malignant phenotypes and poor prognosis by down-regulating ASCL2, and can be a potential target for PAAD clinical diagnosis, prognosis and treatment.
Comparision:Cancer VS Normal
Mechanism:Mechanistically, tRF-18-8R6546D2 promoted PAAD malignancy partly by directly silencing ASCL2 99 and further regulating its downstream genes such as MYC and CASP3.