Entry Detail


General Information

Database ID:TRD05351
Confidence:Very High
Contents:>> tsRNA Information
>> tsRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference



tsRNA Information

tsRNA Name:tRF-16-R29P4PE
tsRNA Type:N/A
Amino acid and Anticodon:N/A
Sequence:GGGGATGTAGCTCAGT
Related Target:PACE4
Predicted Target:GPR84//CDK10//FARP1//C1orf94//WDR55//SGSM2//ENAH//DNASE1L3//GATA1//DYRK2
External Links:
MINTbase ID:tRF-16-R29P4PE
tRFdb ID:N/A

[1] gtRNAdb_ID:tRNA-Ala-AGC-4-1
Anticodon:AlaAGC
tRNA_number:trna120
Chromosome:6
Strand:-
Coordinate:Start Site(bp): 28626070        End Site(bp): 28626085

[2] gtRNAdb_ID:tRNA-Ala-CGC-3-1
Anticodon:AlaCGC
tRNA_number:trna13
Chromosome:2
Strand:+
Coordinate:Start Site(bp): 157257281        End Site(bp): 157257296

[3] gtRNAdb_ID:tRNA-Ala-CGC-2-1
Anticodon:AlaCGC
tRNA_number:trna119
Chromosome:6
Strand:-
Coordinate:Start Site(bp): 28641669        End Site(bp): 28641684

[4] gtRNAdb_ID:tRNA-Ala-CGC-1-1
Anticodon:AlaCGC
tRNA_number:trna10
Chromosome:6
Strand:+
Coordinate:Start Site(bp): 26553731        End Site(bp): 26553746

[5] gtRNAdb_ID:tRNA-Ala-TGC-4-1
Anticodon:AlaTGC
tRNA_number:trna8
Chromosome:12
Strand:+
Coordinate:Start Site(bp): 125424512        End Site(bp): 125424527

[6] gtRNAdb_ID:tRNA-Ala-TGC-3-2
Anticodon:AlaTGC
tRNA_number:trna13
Chromosome:12
Strand:-
Coordinate:Start Site(bp): 125406357        End Site(bp): 125406372

[7] gtRNAdb_ID:tRNA-Ala-TGC-3-1
Anticodon:AlaTGC
tRNA_number:trna8
Chromosome:5
Strand:+
Coordinate:Start Site(bp): 180633868        End Site(bp): 180633883

[8] gtRNAdb_ID:tRNA-Ala-TGC-2-1
Anticodon:AlaTGC
tRNA_number:trna66
Chromosome:6
Strand:+
Coordinate:Start Site(bp): 28611222        End Site(bp): 28611237



tsRNA Association Statistics

Total Associated Disease Number:5
More Information
Network:
(Display the first 15 nodes)



Disease Information

 MeSHDisease Ontology
Disease ID:D006332N/A
Disease Name:CardiomegalyN/A
Category:MeSHDisease Ontology
Type:Cardiovascular Diseases//Pathological Conditions, Signs and SymptomsN/A
Define:Enlargement of the HEART, usually indicated by a cardiothoracic ratio above 0.50. Heart enlargement may involve the right, the left, or both HEART VENTRICLES or HEART ATRIA. Cardiomegaly is a nonspecific symptom seen in patients with chronic systolic heart failure (HEART FAILURE) or several forms of CARDIOMYOPATHIES.N/A
Alias:Cardiac Hypertrophy//Enlarged Heart//Heart Enlargement//Heart HypertrophyN/A



Disease Association Statistics

Total Associated tsRNA Number:68
More Information
Network:
(Display the first 15 nodes)



Evidence Support

Strong Evidence:RT-PCR//Western blot
Weak Evidence:High-throughput sequencing



Reference

[1] PubMed ID:39947523
Disease Name:Cardiomegaly
Tissue:Blood
Dysfunction Pattern:Down-Regulation
Validated Method:RT-PCR//Western blot//High-throughput sequencing
Description:Our results demonstrated that modulating tRF-16-R29P4PE expression significantly reduced brain natriuretic peptide (BNP) and free fatty acid levels while enhancing ATP production, glucose levels, and mitochondrial membrane potential. These effects were accompanied by the downregulation of PACE4, hypoxia-inducible factor-1α (HIF-1α), glucose transporter-4 (GLUT-4), and medium-chain acyl-CoA dehydrogenase (MCAD), as well as the upregulation of peroxisome proliferator-activated receptor α (PPARα). Animal experiments revealed that tRF-16-R29P4PE minic improved cardiac function, reduced myocardial fibrosis, and mitigated metabolic disorders and mitochondrial damage.
Comparision:Disease VS Control
Mechanism:Furthermore, co-immunoprecipitation (Co-IP) and molecular docking assays confirmed a direct interaction between PACE4 and HIF-1α, and luciferase reporter assays identified PACE4 as a direct target of tRF-16-R29P4PE. By regulating the PACE4 and HIF-1α/PPARα signaling pathways, tRF-16-R29P4PE alleviates PCH, providing a promising molecular target for therapeutic intervention.