Entry Detail


General Information

Database ID:TRD05347
Confidence:Very High
Contents:>> tsRNA Information
>> tsRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference



tsRNA Information

tsRNA Name:tRF-16-2YU04DE
tsRNA Type:N/A
Amino acid and Anticodon:N/A
Sequence:CACTGTAAAGCTAACT
Related Target:KLF5
Predicted Target:ANK3//FAM91A1//SNX12//MELTF//HAND2//NCKIPSD//TTLL3//APOB//NDE1//FGF13
External Links:
MINTbase ID:tRF-16-2YU04DE
tRFdb ID:N/A

[1] gtRNAdb_ID:-
Anticodon:LysTTT
tRNA_number:trnaMT
Chromosome:MT
Strand:+
Coordinate:Start Site(bp): 8295        End Site(bp): 8310

[2] gtRNAdb_ID:-
Anticodon:LysTTT
tRNA_number:trnalookalike7
Chromosome:1
Strand:+
Coordinate:Start Site(bp): 568844        End Site(bp): 568859



tsRNA Association Statistics

Total Associated Disease Number:2
More Information
Network:
(Display the first 15 nodes)



Disease Information

 MeSHDisease Ontology
Disease ID:D016889DOID:0050939
Disease Name:Endometrial Neoplasmsuterine corpus endometrial carcinoma
Category:MeSHDisease Ontology
Type:Neoplasms//Urogenital Diseasesdisease of cellular proliferation//disease of anatomical entity
Define:Tumors or cancer of ENDOMETRIUM, the mucous lining of the UTERUS. These neoplasms can be benign or malignant. Their classification and grading are based on the various cell types and the percent of undifferentiated cells.A uterine corpus cancer that is derives_from the inner lining of the uterus.
Alias:Cancer of Endometrium//Cancer of the Endometrium//Carcinoma of Endometrium//Endometrial Cancer//Endometrial Carcinoma//Endometrium Cancer//Neoplasms, EndometrialN/A



Disease Association Statistics

Total Associated tsRNA Number:227
More Information
Network:
(Display the first 15 nodes)



Evidence Support

Strong Evidence:PCR//Western blot//Transfection//Cell proliferation assay//Transwell assay//Cell cycle assay//Cell apoptosis assay
Weak Evidence:High-throughput sequencing



Reference

[1] PubMed ID:40261523
Disease Name:Endometrial Neoplasms
Tissue:Uterus
Dysfunction Pattern:Up-Regulation
Validated Method:PCR//Western blot//Transfection//Cell proliferation assay//Transwell assay//Cell cycle assay//Cell apoptosis assay//High-throughput sequencing
Description:These findings indicate that tRF-16-YU04DE is downregulated in EC and may serve as a pivotal molecule involved in inhibit- ing EC progression。
Comparision:Cancer VS Normal
Mechanism:Bioinformatics analyses combined with RT-qPCR and Western blot results showed KLF5 expression was particularly downregulated by the overexpression of tRF-16-2YU04DE. tRF-16-2YU04DE-inhibiting EC progression in vitro may serve as a promising therapeutic target.