Entry Detail


General Information

Database ID:TRD05346
Confidence:Very High
Contents:>> tsRNA Information
>> tsRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference



tsRNA Information

tsRNA Name:tRF-1020
tsRNA Type:N/A
Amino acid and Anticodon:N/A
Sequence:N/A
Related Target:DVL-2
Predicted Target:N/A
External Links:
MINTbase ID:N/A
tRFdb ID:N/A



tsRNA Association Statistics

Total Associated Disease Number:7
More Information
Network:
(Display the first 15 nodes)



Disease Information

 MeSHDisease Ontology
Disease ID:D003930DOID:13207
Disease Name:Diabetic Retinopathyproliferative diabetic retinopathy
Category:MeSHDisease Ontology
Type:Eye Diseases//Cardiovascular Diseases//Endocrine System Diseasesdisease of anatomical entity//nervous system disease
Define:Disease of the RETINA as a complication of DIABETES MELLITUS. It is characterized by the progressive microvascular complications, such as ANEURYSM, interretinal EDEMA, and intraocular PATHOLOGIC NEOVASCULARIZATION.N/A
Alias:N/APDR



Disease Association Statistics

Total Associated tsRNA Number:86
More Information
Network:
(Display the first 15 nodes)



Evidence Support

Strong Evidence:RT-PCR//Western blot
Weak Evidence:High-throughput sequencing



Reference

[1] PubMed ID:36128646
Disease Name:Diabetic Retinopathy
Tissue:Retina
Dysfunction Pattern:Down-Regulation
Validated Method:RT-PCR//Western blot//High-throughput sequencing
Description:In this study, we mainly investigated the role of tRF‐1020, a tRNA fragment, in diabetes‐induced retinal vascular complications. The result showed that the levels of tRF‐1020 expression were significantly down‐regulated in diabetic retinal vessels, vitreous samples, and aqueous humour samples of DR patients. Increased tRF‐1020 expression could retard the progression of retinal vascular dysfunction via the inactivation of Wnt signalling. TRF‐1020 may serve as a potential target for the diagnosis and treatment of DR.
Comparision:Disease VS Control
Mechanism:In this study, the transfection of tRF‐1020 mimic leads to decreased levels of DVL‐2. By contrast, transfection of tRF‐1020 inhibitor leads to increased levels of DVL‐2. Altered expression of tRF‐1020 could affect the activation of Wnt signalling. This regulatory mechanism provides a novel insight into retinal microvascular complications.