Entry Detail


General Information

Database ID:TRD05344
Confidence:Very High
Contents:>> tsRNA Information
>> tsRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference



tsRNA Information

tsRNA Name:tRF-1:30-Gln-CTG-4
tsRNA Type:N/A
Amino acid and Anticodon:N/A
Sequence:N/A
Related Target:N/A
Predicted Target:N/A
External Links:
MINTbase ID:N/A
tRFdb ID:N/A



tsRNA Association Statistics

Total Associated Disease Number:4
More Information
Network:
(Display the first 15 nodes)



Disease Information

 MeSHDisease Ontology
Disease ID:D003930DOID:13207
Disease Name:Diabetic Retinopathyproliferative diabetic retinopathy
Category:MeSHDisease Ontology
Type:Eye Diseases//Cardiovascular Diseases//Endocrine System Diseasesdisease of anatomical entity//nervous system disease
Define:Disease of the RETINA as a complication of DIABETES MELLITUS. It is characterized by the progressive microvascular complications, such as ANEURYSM, interretinal EDEMA, and intraocular PATHOLOGIC NEOVASCULARIZATION.N/A
Alias:N/APDR



Disease Association Statistics

Total Associated tsRNA Number:86
More Information
Network:
(Display the first 15 nodes)



Evidence Support

Strong Evidence:RT-PCR//Western blot
Weak Evidence:High-throughput sequencing



Reference

[1] PubMed ID:36561608
Disease Name:Diabetic Retinopathy
Tissue:Blood
Dysfunction Pattern:Down-Regulation
Validated Method:RT-PCR//Western blot//High-throughput sequencing
Description:To explore the role of tRFs in TIF during DN progression, the present study performed high-throughput sequencing to detect differential expression profiles of tRFs in high glucose (HG)-treated tubular epithelial cells. Bioinformatics analyses were then conducted on these differentially regulated tRFs (fold change >2, P<0.05). The potential effect of specific tRF was investigated on HG-induced ECM accumulation of tubular epithelial cells. Therefore, the present study attempted to reveal the underlying mechanism of TIF from the novel perspective of tRFs and provide a promising therapeutic target for DN.
Comparision:Disease VS Control
Mechanism:N/A