tsRNADisease

Entry Detail

General Information

Database ID:	TRD05343
Confidence:	Very High
Contents:	>> tsRNA Information >> tsRNA Association Statistics >> Disease Information >> Disease Association Statistics >> Evidence Support >> Reference

tsRNA Information

tsRNA Name:

tRF-1:28-Val-CAC-2

tsRNA Type:

N/A

Amino acid and Anticodon:

N/A

Sequence:

N/A

Related Target:

Predicted Target:

External Links:

MINTbase ID:	N/A
tRFdb ID:	N/A

tsRNA Association Statistics

Total Associated Disease Number:	13 More Information
Network: (Display the first 15 nodes)

Disease Information

	MeSH	Disease Ontology
Disease ID:	D009303	DOID:9561
Disease Name:	Nasopharyngeal Neoplasms	nasopharyngeal disease
Category:	MeSH	Disease Ontology
Type:	Neoplasms//Stomatognathic Diseases//Otorhinolaryngologic Diseases	disease of anatomical entity
Define:	Tumors or cancer of the NASOPHARYNX.	N/A
Alias:	Cancer of Nasopharynx//Cancer of the Nasopharynx//Nasopharyngeal Cancer//Nasopharynx Cancer//Nasopharynx Neoplasms//Neoplasms, Nasopharyngeal	N/A

Disease Association Statistics

Total Associated tsRNA Number:	1 More Information
Network: (Display the first 15 nodes)

Evidence Support

Strong Evidence:	PCR//Western blot//Transfection//Cell proliferation assay//Transwell assay//Cell cycle assay//Cell apoptosis assay//Luciferase reporter assay//Pull down assay
Weak Evidence:	tRF and tiRNA arrays

Reference

[1] PubMed ID:	40485734
Disease Name:	Nasopharyngeal Neoplasms
Tissue:	Nasopharynx
Dysfunction Pattern:	Up-Regulation
Validated Method:	PCR//Western blot//Transfection//Cell proliferation assay//Transwell assay//Cell cycle assay//Cell apoptosis assay//Luciferase reporter assay//Pull down assay//tRF and tiRNA arrays
Description:	NPC exhibit the upregulation of tRF-1:28-Val-CAC-2, which promotes proliferative activity
Comparision:	Cancer VS Normal
Mechanism:	At a mechanistic level, these effects were related to the control of EPHB2 gene expression by tRF-1:28 Val-CAC-2, thereby shaping the survival and malignancy of the cells.