Entry Detail


General Information

Database ID:TRD05336
Confidence:High
Contents:>> tsRNA Information
>> tsRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference



tsRNA Information

tsRNA Name:TiRNA-Gly-GCC-002
tsRNA Type:N/A
Amino acid and Anticodon:N/A
Sequence:N/A
Related Target:N/A
Predicted Target:N/A
External Links:
MINTbase ID:N/A
tRFdb ID:N/A



tsRNA Association Statistics

Total Associated Disease Number:2
More Information
Network:
(Display the first 15 nodes)



Disease Information

 MeSHDisease Ontology
Disease ID:D006528DOID:684
Disease Name:Carcinoma, Hepatocellularhepatocellular carcinoma
Category:MeSHDisease Ontology
Type:Neoplasms//Digestive System Diseasesdisease of anatomical entity//disease of cellular proliferation
Define:A primary malignant neoplasm of epithelial liver cells. It ranges from a well-differentiated tumor with EPITHELIAL CELLS indistinguishable from normal HEPATOCYTES to a poorly differentiated neoplasm. The cells may be uniform or markedly pleomorphic, or form GIANT CELLS. Several classification schemes have been suggested.A liver carcinoma that has_material_basis_in undifferentiated hepatocytes and located_in the liver.
Alias:Hepatocellular Carcinoma//Hepatoma//Liver Cancer, Adult//Liver Cell Carcinoma//Liver Cell Carcinoma, AdultHepatoma



Disease Association Statistics

Total Associated tsRNA Number:61
More Information
Network:
(Display the first 15 nodes)



Evidence Support

Strong Evidence:RT-PCR
Weak Evidence:Sequencing



Reference

[1] PubMed ID:39430835
Disease Name:Carcinoma, Hepatocellular
Tissue:Liver
Dysfunction Pattern:Up-Regulation
Validated Method:RT-PCR//Sequencing
Description:We verified the expression levels of these tRNA-derived fragments in the tissues of 6 patients using PCR. The result revealed that 5 tRNA-derived fragments (tRF-Ala-AGC-060, tiRNA-Gly-GCC-002, tRF-Ala-AGC-010, tRF-Leu-AAG-001 and tRF-Gly-GCC-011) were significantly higher in the tumor tissues versus paracancerous tissues.
Comparision:Cancer VS Normal
Mechanism:Function analysis indicated that tiRNA-Gly-GCC-002 was primarily involved in adenyl nucleotide binding, cell cycle, cell cycle process and chromosome organization. We found that patients with high expression level of tiRNA-Gly-GCC-002 had worse prognosis than low expression level. The univariable and multivariable Cox regression analyses showed that tiRNAGly-GCC-002 was an important prognostic factor. Furthermore, the nomogram by combining tiRNA-Gly-GCC-002 expression level (P=0.03) And serum gamma-glutamyl transferase (GGT) level (P=0.001) Was established to predict the prognosis of patients with HCC [concordance index (C-index): 0.789].