Entry Detail


General Information

Database ID:TRD05292
Confidence:High
Contents:>> tsRNA Information
>> tsRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference



tsRNA Information

tsRNA Name:AS-tDR-002338
tsRNA Type:N/A
Amino acid and Anticodon:N/A
Sequence:N/A
Related Target:N/A
Predicted Target:N/A
External Links:
MINTbase ID:N/A
tRFdb ID:N/A



tsRNA Association Statistics

Total Associated Disease Number:3
More Information
Network:
(Display the first 15 nodes)



Disease Information

 MeSHDisease Ontology
Disease ID:D009402N/A
Disease Name:Nephrosis, LipoidN/A
Category:MeSHDisease Ontology
Type:Urogenital DiseasesN/A
Define:A kidney disease with no or minimal histological glomerular changes on light microscopy and with no immune deposits. It is characterized by lipid accumulation in the epithelial cells of KIDNEY TUBULES and in the URINE. Patients usually show NEPHROTIC SYNDROME indicating the presence of PROTEINURIA with accompanying EDEMA.N/A
Alias:Glomerulonephritis, Minimal Change//Glomerulopathy, Minimal Change//Idiopathic Minimal Change Nephrotic Syndrome//Minimal Change Disease//Minimal Change Glomerulopathy//Minimal Change Nephrotic Syndrome//Nephropathy, Minimal Change//Nephrotic Syndrome, Minimal ChangeN/A



Disease Association Statistics

Total Associated tsRNA Number:32
More Information
Network:
(Display the first 15 nodes)



Evidence Support

Strong Evidence:RT-PCR
Weak Evidence:N/A



Reference

[1] PubMed ID:32685525
Disease Name:Nephrosis, Lipoid
Tissue:Podocyte
Dysfunction Pattern:Down-Regulation
Validated Method:RT-PCR//NA
Description:This study intends to explore the changes in and importance of tRFs during podocyte injury in vitro and to further analyze the potential mechanism of INS. Differentially expressed tRFs in the adriamycin-treated group were identified by high-throughput sequencing and further verified by quantitative RT-PCR. In total, 203 tRFs with significant differential expression were identified, namely, 102 upregulated tRFs and 101 downregulated tRFs (q < 0.05, ∣Log2FC | ≥2). In particular, AS-tDR-008924, AS-tDR-011690, tDR-003634, AS-tDR-013354, tDR-011031, AS-tDR-001008, and AS-tDR-007319 were predicted to be involved in podocyte injury by targeting the Gpr, Wnt, Rac1, and other genes.
Comparision:Disease VS Control
Mechanism:N/A