tsRNADisease

Entry Detail

General Information

Database ID:	TRD05104
Confidence:	Very High
Contents:	>> tsRNA Information >> tsRNA Association Statistics >> Disease Information >> Disease Association Statistics >> Evidence Support >> Reference

tsRNA Information

tsRNA Name:

tRF-3Thr-CGT

tsRNA Type:

N/A

Amino acid and Anticodon:

ThrCGT

Sequence:

N/A

Related Target:

Predicted Target:

External Links:

MINTbase ID:	N/A
tRFdb ID:	N/A

tsRNA Association Statistics

Total Associated Disease Number:	1 More Information
Network: (Display the first 15 nodes)

Disease Information

	MeSH	Disease Ontology
Disease ID:	D006528	DOID:684
Disease Name:	Carcinoma, Hepatocellular	hepatocellular carcinoma
Category:	MeSH	Disease Ontology
Type:	Neoplasms//Digestive System Diseases	disease of anatomical entity//disease of cellular proliferation
Define:	A primary malignant neoplasm of epithelial liver cells. It ranges from a well-differentiated tumor with EPITHELIAL CELLS indistinguishable from normal HEPATOCYTES to a poorly differentiated neoplasm. The cells may be uniform or markedly pleomorphic, or form GIANT CELLS. Several classification schemes have been suggested.	A liver carcinoma that has_material_basis_in undifferentiated hepatocytes and located_in the liver.
Alias:	Hepatocellular Carcinoma//Hepatoma//Liver Cancer, Adult//Liver Cell Carcinoma//Liver Cell Carcinoma, Adult	Hepatoma

Disease Association Statistics

Total Associated tsRNA Number:	61 More Information
Network: (Display the first 15 nodes)

Evidence Support

Strong Evidence:	PCR//Western blot//Transfection//Transwell assay
Weak Evidence:	Sequencing

Reference

[1] PubMed ID:	40520188
Disease Name:	Carcinoma, Hepatocellular
Tissue:	Liver
Dysfunction Pattern:	Up-Regulation
Validated Method:	PCR//Western blot//Transfection//Transwell assay//Sequencing
Description:	We found that hypoxic stress altered their subtype distributions and that the high expression of tRF-3Thr-CGT, which has functions in transcription and translation regulation, may potentially bind to the 3'-UTR of HsPDF. Upregulated tRF-3Thr-CGTcould inhibit HsPDF and mitochondrial OXPHOS function.
Comparision:	Cancer VS Normal
Mechanism:	Furthermore, the orthotopic liver cancer model in mice also indicated that the tRF-3Thr-CGTinhibitor significantly suppressed tumor progression. These results collectively suggested that tRFs may have roles in mitochondrial protein coordination and become novel pharmacological targets for mitochondrial remodeling under tumor microenvironment remodeling of HCC therapy.