Entry Detail


General Information

Database ID:TRD04936
Confidence:High
Contents:>> tsRNA Information
>> tsRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference



tsRNA Information

tsRNA Name:tRF-Met-CAT-008
tsRNA Type:N/A
Amino acid and Anticodon:MetCAT
Sequence:N/A
Related Target:Apc2; Rnf145; Sall3; Med13l; Sucla2
Predicted Target:N/A
External Links:
MINTbase ID:N/A
tRFdb ID:N/A



tsRNA Association Statistics

Total Associated Disease Number:11
More Information
Network:
(Display the first 15 nodes)



Disease Information

 MeSHDisease Ontology
Disease ID:D017202N/A
Disease Name:Myocardial IschemiaN/A
Category:MeSHDisease Ontology
Type:Cardiovascular DiseasesN/A
Define:A disorder of cardiac function caused by insufficient blood flow to the muscle tissue of the heart. The decreased blood flow may be due to narrowing of the coronary arteries (CORONARY ARTERY DISEASE), to obstruction by a thrombus (CORONARY THROMBOSIS), or less commonly, to diffuse narrowing of arterioles and other small vessels within the heart. Severe interruption of the blood supply to the myocardial tissue may result in necrosis of cardiac muscle (MYOCARDIAL INFARCTION).N/A
Alias:Heart Disease, Ischemic//Ischemia, Myocardial//Ischemic Heart DiseaseN/A



Disease Association Statistics

Total Associated tsRNA Number:59
More Information
Network:
(Display the first 15 nodes)



Evidence Support

Strong Evidence:RT-PCR
Weak Evidence:High-throughput sequencing



Reference

[1] PubMed ID:33224944
Disease Name:Myocardial Ischemia
Tissue:Rat Cardiomyocyte Cell Line
Dysfunction Pattern:Down-Regulation
Validated Method:RT-PCR//High-throughput sequencing
Description:A target mRNA was randomly selected from each tsRNA, and the results of four analyzed tsRNAs were consistent with the predicted results, with the exception of tRF-Gly-TCC-018.
Comparision:CR VS Norm;CR+MI VS MI
Mechanism:Except for the target gene of tRF-Gly-TCC-018, when the expression levels of tiRNA-His-GTG-004 were downregulated in the MI group and upregulated in the CR + MI group, the expression levels of the corresponding mRNA Mastl were upregulated in the MI group and downregulated in the CR+MI group.