tsRNADisease

Entry Detail

General Information

Database ID:	TRD04888
Confidence:	Very High
Contents:	>> tsRNA Information >> tsRNA Association Statistics >> Disease Information >> Disease Association Statistics >> Evidence Support >> Reference

tsRNA Information

tsRNA Name:

tsRNA

tsRNA Type:

N/A

Amino acid and Anticodon:

LysCTT

Sequence:

N/A

Related Target:

Predicted Target:

External Links:

MINTbase ID:	N/A
tRFdb ID:	N/A

tsRNA Association Statistics

Total Associated Disease Number:	1 More Information
Network: (Display the first 15 nodes)

Disease Information

	MeSH	Disease Ontology
Disease ID:	D001749	DOID:4006
Disease Name:	Urinary Bladder Neoplasms	bladder urothelial carcinoma
Category:	MeSH	Disease Ontology
Type:	Neoplasms//Urogenital Diseases	disease of cellular proliferation//disease of anatomical entity
Define:	Tumors or cancer of the URINARY BLADDER.	A bladder carcinoma that has_material_basis_in transitional cells located_in the lining of the bladder.
Alias:	Bladder Cancer//Bladder Neoplasms//Bladder Tumors//Cancer of Bladder//Cancer of the Bladder//Malignant Tumor of Urinary Bladder//Neoplasms, Bladder//Urinary Bladder Cancer	bladder transitional cell carcinoma//transitional cell carcinoma of bladder//urinary bladder urothelial carcinoma//urothelial bladder carcinoma

Disease Association Statistics

Total Associated tsRNA Number:	41 More Information
Network: (Display the first 15 nodes)

Evidence Support

Strong Evidence:	qPCR
Weak Evidence:	High-throughput sequencing

Reference

[1] PubMed ID:	33291319
Disease Name:	Urinary Bladder Neoplasms
Tissue:	N/A
Dysfunction Pattern:	N/A
Validated Method:	qPCR//High-throughput sequencing
Description:	this is the first study of the clinical value of tRFs in bladder urothelial carcinoma. 5 0 -tRF-LysCTT was analyzed in a screening cohort of 230 BlCa patients, where higher 50 -tRF-LysCTT levels were correlated with unfavorable disease prognostic features, including muscle-invasive and HG tumors, as well as high EORTC-risk group and positive FFC of the NMIBC group.
Comparision:	N/A
Mechanism:	stages following TURBT, and (b) significantly worse DFS and OS of MIBC patients following RC. In this regard, the elevated 50 -tRF-LysCTT levels were highlighted, by multivariate regression models, as an independent predictor of the short-term progression and the poor survival expectancy of NMIBC and MIBC patients, respectively. TCGA-BLCA (consisted mostly of MIBC patients) was used as validation cohort in our study.