| [1] PubMed ID: | 35585048 |
| Disease Name: | Stomach Neoplasms |
| Tissue: | Stomach |
| Dysfunction Pattern: | Up-Regulation |
| Validated Method: | PCR//High-throughput sequencing |
| Description: | The results showed that tRF-58:75-Ala-AGC-1, tRF-69:86-Leu-CAG-1, tRF-60:76-Val-CAC-2, and tRF-59:75-Gln-TTG-1-M3 were significantly upregulated and tRF-60:76-Val-CAC-2 (hereinafter referred to as tRF-Val) was the most significantly upregulated one (P = 0.002) in 10 GC tissues compared with matched normal tissues (Fig. (Fig.2F).2F). |
| Comparision: | Cancer VS Normal |
| Mechanism: | tRF-Val expression was positively correlated with tumor size and the depth of tumor invasion in GC tissues. Functionally, tRF-Val promoted proliferation and invasion, and inhibited apoptosis in GC cells. Mechanistically, tRF-Val directly bound to the chaperone molecule EEF1A1, mediated its transport into the nucleus and promoted its interaction with MDM2 (a specific p53 E3 ubiquitin ligase), thus inhibiting the downstream molecular pathway of p53 and promoting GC progression. |
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