Entry Detail


General Information

Database ID:TRD04784
Confidence:Very High
Contents:>> tsRNA Information
>> tsRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference



tsRNA Information

tsRNA Name:tRF-Leu-AAG-001
tsRNA Type:N/A
Amino acid and Anticodon:LeuAAG
Sequence:ATCCCACCGCTGCCACCA
Related Target:N/A
Predicted Target:ZNF853//KIF3B//MAML2//APOBR//VAX2//PHF19//POU3F3//RAN//ANKIB1//NGB
External Links:
MINTbase ID:tRF-18-HR0VX6D2
tRFdb ID:N/A

[1] gtRNAdb_ID:tRNA-Leu-AAG-4-1
Anticodon:LeuAAG
tRNA_number:trna126
Chromosome:6
Strand:-
Coordinate:Start Site(bp): 28446400-3        End Site(bp): 28446414

[2] gtRNAdb_ID:tRNA-Leu-AAG-3-1
Anticodon:LeuAAG
tRNA_number:trna78
Chromosome:6
Strand:+
Coordinate:Start Site(bp): 28956846        End Site(bp): 28956860+3

[3] gtRNAdb_ID:tRNA-Leu-AAG-2-3
Anticodon:LeuAAG
tRNA_number:trna1
Chromosome:14
Strand:+
Coordinate:Start Site(bp): 21078358        End Site(bp): 21078372+3

[4] gtRNAdb_ID:tRNA-Leu-AAG-2-4
Anticodon:LeuAAG
tRNA_number:trna16
Chromosome:16
Strand:+
Coordinate:Start Site(bp): 22308528        End Site(bp): 22308542+3

[5] gtRNAdb_ID:tRNA-Leu-AAG-2-1
Anticodon:LeuAAG
tRNA_number:trna7
Chromosome:5
Strand:+
Coordinate:Start Site(bp): 180614768        End Site(bp): 180614782+3

[6] gtRNAdb_ID:tRNA-Leu-AAG-2-2
Anticodon:LeuAAG
tRNA_number:trna98
Chromosome:6
Strand:-
Coordinate:Start Site(bp): 28911399-3        End Site(bp): 28911413

[7] gtRNAdb_ID:tRNA-Leu-AAG-1-3
Anticodon:LeuAAG
tRNA_number:trna16
Chromosome:5
Strand:-
Coordinate:Start Site(bp): 180601044-3        End Site(bp): 180601058

[8] gtRNAdb_ID:tRNA-Leu-AAG-1-1
Anticodon:LeuAAG
tRNA_number:trna19
Chromosome:5
Strand:-
Coordinate:Start Site(bp): 180524474-3        End Site(bp): 180524488

[9] gtRNAdb_ID:tRNA-Leu-AAG-1-2
Anticodon:LeuAAG
tRNA_number:trna3
Chromosome:5
Strand:+
Coordinate:Start Site(bp): 180528907        End Site(bp): 180528921+3

[10] gtRNAdb_ID:tRNA-Leu-TAG-3-1
Anticodon:LeuTAG
tRNA_number:trna27
Chromosome:16
Strand:-
Coordinate:Start Site(bp): 22207032-3        End Site(bp): 22207046

[11] gtRNAdb_ID:tRNA-Leu-TAG-1-1
Anticodon:LeuTAG
tRNA_number:trna42
Chromosome:17
Strand:-
Coordinate:Start Site(bp): 8023632-3        End Site(bp): 8023646



tsRNA Association Statistics

Total Associated Disease Number:6
More Information
Network:
(Display the first 15 nodes)



Disease Information

 MeSHDisease Ontology
Disease ID:D004715DOID:289
Disease Name:Endometriosisendometriosis
Category:MeSHDisease Ontology
Type:Urogenital Diseasesdisease of anatomical entity
Define:A condition in which functional endometrial tissue is present outside the UTERUS. It is often confined to the PELVIS involving the OVARY, the ligaments, cul-de-sac, and the uterovesical peritoneum. A female reproductive system disease characterized by the growth of endometrial tissue outside the uterine body.
Alias:EndometriomaN/A



Disease Association Statistics

Total Associated tsRNA Number:12
More Information
Network:
(Display the first 15 nodes)



Evidence Support

Strong Evidence:RT-PCR//Western blot
Weak Evidence:High-throughput sequencing



Reference

[1] PubMed ID:35752827
Disease Name:Endometriosis
Tissue:exosomes
Dysfunction Pattern:Up-Regulation
Validated Method:RT-PCR//Western blot//High-throughput sequencing
Description:63 Up-regulated and 45 down-regulated tRFs&tiRNAs were identified in ectopic exosomes. We selected tRF-Leu-AAG-001 as a candidate marker through KEGG pathway enrichment and PCR verification. We found that mast cells highly expressed tRF-Leu-AAG-001 in ectopic foci by immunofluorescence staining. We used siRNA to silenced tRF-Leu-AAG-001 expression in luva, qPCR analysis showed IL-6, IL-10, IL-1β, and TNF-α were significantly decreased. Meanwhile, tRF-Leu-AAG-001 siRNA dramatically reduced the angiogenic ability of luva. Finally, we examined the expression of exosomal tRF-Leu-AAG-001 in the leucorrhea. It was found exosomal tRF-Leu-AAG-001 had high specificity and sensitivity for predicting the occurrence of ectopic disease.
Comparision:Disease VS Control
Mechanism:N/A