Entry Detail


General Information

Database ID:TRD04739
Confidence:Very High
Contents:>> tsRNA Information
>> tsRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference



tsRNA Information

tsRNA Name:tRF-His-GTG-1
tsRNA Type:N/A
Amino acid and Anticodon:HisGTG
Sequence:N/A
Related Target:TLR8
Predicted Target:N/A
External Links:
MINTbase ID:N/A
tRFdb ID:N/A



tsRNA Association Statistics

Total Associated Disease Number:1
More Information
Network:
(Display the first 15 nodes)



Disease Information

 MeSHDisease Ontology
Disease ID:D008180DOID:9074
Disease Name:Lupus Erythematosus, Systemicsystemic lupus erythematosus
Category:MeSHDisease Ontology
Type:Skin and Connective Tissue Diseases//Immune System Diseasesdisease of anatomical entity
Define:A chronic, relapsing, inflammatory, and often febrile multisystemic disorder of connective tissue, characterized principally by involvement of the skin, joints, kidneys, and serosal membranes. It is of unknown etiology, but is thought to represent a failure of the regulatory mechanisms of the autoimmune system. The disease is marked by a wide range of system dysfunctions, an elevated erythrocyte sedimentation rate, and the formation of LE cells in the blood or bone marrow.A lupus erythematosus that is an inflammation of connective tissue marked by skin rashes, joint pain and swelling, inflammation of the kidneys and inflammation of the tissue surrounding the heart.
Alias:Libman-Sacks Disease//Lupus Erythematosus Disseminatus//Systemic Lupus Erythematosusdisseminated lupus erythematosus//Lupus Erythematosus, systemic//SLE - Lupus Erythematosus, systemic



Disease Association Statistics

Total Associated tsRNA Number:111
More Information
Network:
(Display the first 15 nodes)



Evidence Support

Strong Evidence:RT-PCR//Western blot
Weak Evidence:High-throughput sequencing



Reference

[1] PubMed ID:38972975
Disease Name:Lupus Erythematosus, Systemic
Tissue:Blood
Dysfunction Pattern:Up-Regulation
Validated Method:RT-PCR//Western blot//High-throughput sequencing
Description:Increased circulating NETs DNA and pEVs were shown in SLE patients and were associated with disease activity (P < 0.005). We demonstrated that SLE patient-derived immune complexes (ICs) induced platelet activation, followed by pEVs release. ICs-triggered NETs formation was significantly enhanced in the presence of pEVs through Toll-like receptor (TLR) 8 activation. Increased levels of tRF-His-GTG-1 in pEVs and neutrophils of SLE patients were associated with disease activity.
Comparision:Disease VS Control
Mechanism:TRF-His-GTG-1 interacted with TLR8 to prime p47phox phosphorylation in neutrophils, resulting in reactive oxygen species production and NETs formation. Additionally, tRF-His-GTG-1 modulated NF-魏B and IRF7 activation in neutrophils upon TLR8 engagement, resulting IL-1尾, IL-8, and interferon-伪 upregulation, respectively.