Entry Detail


General Information

Database ID:TRD04642
Confidence:Median
Contents:>> tsRNA Information
>> tsRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference



tsRNA Information

tsRNA Name:tRNA-GlyGCC_n1
tsRNA Type:N/A
Amino acid and Anticodon:GlyGCC
Sequence:GCGGATATAGTCGAATG
Related Target:N/A
Predicted Target:GNAI2//ZSWIM8//PPFIA4//GART//TEX45//SNU13//DLG2//IFT140//GLI3//GGA2
External Links:
MINTbase ID:N/A
tRFdb ID:N/A



tsRNA Association Statistics

Total Associated Disease Number:11
More Information
Network:
(Display the first 15 nodes)



Disease Information

 MeSHDisease Ontology
Disease ID:D017202N/A
Disease Name:Myocardial IschemiaN/A
Category:MeSHDisease Ontology
Type:Cardiovascular DiseasesN/A
Define:A disorder of cardiac function caused by insufficient blood flow to the muscle tissue of the heart. The decreased blood flow may be due to narrowing of the coronary arteries (CORONARY ARTERY DISEASE), to obstruction by a thrombus (CORONARY THROMBOSIS), or less commonly, to diffuse narrowing of arterioles and other small vessels within the heart. Severe interruption of the blood supply to the myocardial tissue may result in necrosis of cardiac muscle (MYOCARDIAL INFARCTION).N/A
Alias:Heart Disease, Ischemic//Ischemia, Myocardial//Ischemic Heart DiseaseN/A



Disease Association Statistics

Total Associated tsRNA Number:59
More Information
Network:
(Display the first 15 nodes)



Evidence Support

Strong Evidence:N/A
Weak Evidence:High-throughput sequencing



Reference

[1] PubMed ID:36090756
Disease Name:Myocardial Ischemia
Tissue:Cardiomyocyte
Dysfunction Pattern:Up-Regulation
Validated Method:High-throughput sequencing
Description:In contrast, no significant effects were observed with TEF similarly prepared from other TCMs, such as ganoderma and toad venom, which served as negative controls.
Comparision:TEF VS Control
Mechanism:We reported for the first time that a 22-mer double-strand RNA consisting of HC83 (a tRNA-derived fragment [tRF] from the 3′ end of tRNAGln(UUG) of ginseng) and its complementary sequence significantly promoted H9c2 cell survival after hypoxia/reoxygenation (H/R) in vitro. HC83_mimic could also significantly improve cardiac function by maintaining both cytoskeleton integrity and mitochondrial function of cardiomyocytes. Further in vivo investigations revealed that HC83_mimic is more potent than metoprolol by >500-fold against myocardial ischemia/reperfusion (MI/R) injury. In-depth studies revealed that HC83 directly downregulated a lncRNA known as myocardial infarction-associated transcript (MIAT) that led to a subsequent upregulation of VEGFA expression.