Entry Detail


General Information

Database ID:TRD04419
Confidence:Median
Contents:>> tsRNA Information
>> tsRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference



tsRNA Information

tsRNA Name:tRFs4
tsRNA Type:N/A
Amino acid and Anticodon:GlnCTG
Sequence:GGTTCCATGGTGTAATGGTTAGCACTCTGGACTC
Related Target:N/A
Predicted Target:NEFL//SLC25A48//DISC1//WDR66//RPL41//TSNAX-DISC1//FAM92B//C10orf67//EIF4ENIF1//GCNA
External Links:
MINTbase ID:tRF-34-R9J89O9NF5W8E5
tRFdb ID:N/A

[1] gtRNAdb_ID:tRNA-Gln-CTG-5-1
Anticodon:GlnCTG
tRNA_number:trna42
Chromosome:6
Strand:+
Coordinate:Start Site(bp): 27263212        End Site(bp): 27263245

[2] gtRNAdb_ID:tRNA-Gln-CTG-2-1
Anticodon:GlnCTG
tRNA_number:trna146
Chromosome:6
Strand:-
Coordinate:Start Site(bp): 27515569        End Site(bp): 27515602

[3] gtRNAdb_ID:tRNA-Gln-CTG-1-4
Anticodon:GlnCTG
tRNA_number:trna7
Chromosome:15
Strand:-
Coordinate:Start Site(bp): 66161438        End Site(bp): 66161471

[4] gtRNAdb_ID:tRNA-Gln-CTG-1-5
Anticodon:GlnCTG
tRNA_number:trna3
Chromosome:17
Strand:+
Coordinate:Start Site(bp): 8023070        End Site(bp): 8023103

[5] gtRNAdb_ID:tRNA-Gln-CTG-1-1
Anticodon:GlnCTG
tRNA_number:trna1
Chromosome:6
Strand:+
Coordinate:Start Site(bp): 18836402        End Site(bp): 18836435

[6] gtRNAdb_ID:tRNA-Gln-CTG-1-2
Anticodon:GlnCTG
tRNA_number:trna49
Chromosome:6
Strand:+
Coordinate:Start Site(bp): 27487308        End Site(bp): 27487341

[7] gtRNAdb_ID:tRNA-Gln-CTG-1-3
Anticodon:GlnCTG
tRNA_number:trna99
Chromosome:6
Strand:-
Coordinate:Start Site(bp): 28909416        End Site(bp): 28909449



tsRNA Association Statistics

Total Associated Disease Number:12
More Information
Network:
(Display the first 15 nodes)



Disease Information

 MeSHDisease Ontology
Disease ID:D002312DOID:11984
Disease Name:Cardiomyopathy, Hypertrophichypertrophic cardiomyopathy
Category:MeSHDisease Ontology
Type:Cardiovascular Diseasesdisease of anatomical entity
Define:A form of CARDIAC MUSCLE disease, characterized by left and/or right ventricular hypertrophy (HYPERTROPHY, LEFT VENTRICULAR; HYPERTROPHY, RIGHT VENTRICULAR), frequent asymmetrical involvement of the HEART SEPTUM, and normal or reduced left ventricular volume. Risk factors include HYPERTENSION; AORTIC STENOSIS; and gene MUTATION; (FAMILIAL HYPERTROPHIC CARDIOMYOPATHY).An intrinsic cardiomyopathy that is characterized by abnormal thickening (hypertrophy) of the heart without any obvious cause.
Alias:Cardiomyopathy, Hypertrophic Obstructivehypertrophic obstructive cardiomyopathy



Disease Association Statistics

Total Associated tsRNA Number:66
More Information
Network:
(Display the first 15 nodes)



Evidence Support

Strong Evidence:N/A
Weak Evidence:High-throughput sequencing



Reference

[1] PubMed ID:30012983
Disease Name:Cardiomyopathy, Hypertrophic
Tissue:Heart
Dysfunction Pattern:Up-Regulation
Validated Method:High-throughput sequencing
Description:Luciferase reporter assay identified that tRFs1 directly target 3′UTR of Timp3. tRFs1, tRFs2, tRFs3, and tRFs4 were also highly expressed in Hyp F0 sperm and in Hyp F2 offspring hearts
Comparision:Hyp VS Control
Mechanism:Compared to Con F1 offspring, Hyp F1 offspring had elevated expression levels of β-MHC and ANP genes, and they had increased fibrosis and apoptosis in their hearts. These results demonstrated that tRFs are involved in regulating the response of myocardial hypertrophy. Besides, tRFs might serve as novel epigenetic factors that contribute to the intergenerational inheritance of cardiac hypertrophy.