| [1] PubMed ID: | 23183536 |
| Disease Name: | respiratory syncytial virus infectious disease |
| Tissue: | Lung |
| Dysfunction Pattern: | Up-Regulation |
| Validated Method: | PCR//Western blot//High-throughput sequencing |
| Description: | RSV infection leads to abundant production of transfer RNA (tRNA)-derived RNA Fragments (tRFs) that are ~30 nucleotides (nts) long and correspond to the 5′-half of mature tRNAs. At least one tRF, which is derived from tRNA-Glu-CTC, represses target mRNA in the cytoplasm and promotes RSV replication. |
| Comparision: | Disease VS Control |
| Mechanism: | This demonstrates that this tRF is not a random by-product of tRNA degradation but a functional molecule. The biogenesis of this tRF is also specific, as it is mediated by the endonuclease angiogenin (ANG), not by other nucleases. In summary, our study presents novel information on the induction of a functional tRF by viral infection. |
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