tsRNADisease

Entry Detail

General Information

Database ID:	TRD04140
Confidence:	Median
Contents:	>> tsRNA Information >> tsRNA Association Statistics >> Disease Information >> Disease Association Statistics >> Evidence Support >> Reference

tsRNA Information

tsRNA Name:

tRNA-ala

tsRNA Type:

tRF-5

Amino acid and Anticodon:

N/A

Sequence:

N/A

Related Target:

Predicted Target:

External Links:

MINTbase ID:	N/A
tRFdb ID:	N/A

tsRNA Association Statistics

Total Associated Disease Number:	1 More Information
Network: (Display the first 15 nodes)

Disease Information

	MeSH	Disease Ontology
Disease ID:	D009190	DOID:0050908
Disease Name:	Myelodysplastic Syndromes	myelodysplastic syndrome
Category:	MeSH	Disease Ontology
Type:	Hemic and Lymphatic Diseases	disease of anatomical entity//disease of cellular proliferation
Define:	Clonal hematopoietic stem cell disorders characterized by dysplasia in one or more hematopoietic cell lineages. They predominantly affect patients over 60, are considered preleukemic conditions, and have high probability of transformation into ACUTE MYELOID LEUKEMIA.	A bone marrow cancer that is characterized by under production of white blood cells, red blood cells and platelets.
Alias:	Dysmyelopoietic Syndromes//Hematopoetic Myelodysplasia	N/A

Disease Association Statistics

Total Associated tsRNA Number:	83 More Information
Network: (Display the first 15 nodes)

Evidence Support

Strong Evidence:	N/A
Weak Evidence:	High-throughput sequencing

Reference

[1] PubMed ID:	29628141
Disease Name:	Myelodysplastic Syndromes
Tissue:	Hescs
Dysfunction Pattern:	Down-Regulation
Validated Method:	High-throughput sequencing
Description:	ψ is critically required for 50tRF-dependent translational repression in vivo.
Comparision:	PUS7-KO VS WT
Mechanism:	Mechanistically, the ψ ''writer'' PUS7 modifies and activates a novel network of tRNA-derived small fragments (tRFs) targeting the translation initiation complex. PUS7 inactivation in embryonic stem cells impairs tRF-mediated translation regulation, leading to increased protein biosynthesis and defective germ layer specification.