tsRNADisease

Entry Detail

General Information

Database ID:	TRD04131
Confidence:	High
Contents:	>> tsRNA Information >> tsRNA Association Statistics >> Disease Information >> Disease Association Statistics >> Evidence Support >> Reference

tsRNA Information

tsRNA Name:

5'Tyr-tRF

tsRNA Type:

tRF-5

Amino acid and Anticodon:

N/A

Sequence:

N/A

Related Target:

Predicted Target:

External Links:

MINTbase ID:	N/A
tRFdb ID:	N/A

tsRNA Association Statistics

Total Associated Disease Number:	1 More Information
Network: (Display the first 15 nodes)

Disease Information

	MeSH	Disease Ontology
Disease ID:
Disease Name:
Category:
Type:
Define:
Alias:

Disease Association Statistics

Total Associated tsRNA Number:	1 More Information
Network: (Display the first 15 nodes)

Evidence Support

Strong Evidence:	Transfection
Weak Evidence:	N/A

Reference

[1] PubMed ID:	32143824
Disease Name:	Neuronal Defects
Tissue:	N/A
Dysfunction Pattern:	Up-Regulation
Validated Method:	Transfection
Description:	Tyrosine pre-transfer RNA fragments are linked to p53-dependent neuronal cell death via PKM2.
Comparision:	N/A
Mechanism:	5'Tyr-tRF bound directly to pyruvate kinase M2 (PKM2). Injection of zebrafish embryos with PKM2 mRNA ameliorated the neuronal defects induced in zebrafish embryos by 5'Tyr-tRF.