Entry Detail


General Information

Database ID:TRD04086
Confidence:High
Contents:>> tsRNA Information
>> tsRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference



tsRNA Information

tsRNA Name:tRF5-ValCAC
tsRNA Type:tRF-5
Amino acid and Anticodon:ValCAC
Sequence:GTTTCCGTAGTGTAGTGGTTATCACGTTCGC
Related Target:N/A
Predicted Target:SLC12A5//CTNND2//CLSTN3//TNFRSF10B//CLPB//SREBF2//RABGAP1//OPLAH//FAM171A1//NLRC5
External Links:
MINTbase ID:tRF-31-79MP9P9NH57SD
tRFdb ID:N/A

[1] gtRNAdb_ID:tRNA-Val-AAC-4-1
Anticodon:ValAAC
tRNA_number:trna136
Chromosome:6
Strand:-
Coordinate:Start Site(bp): 27648927        End Site(bp): 27648957

[2] gtRNAdb_ID:tRNA-Val-AAC-3-1
Anticodon:ValAAC
tRNA_number:trna139
Chromosome:6
Strand:-
Coordinate:Start Site(bp): 27618749        End Site(bp): 27618779

[3] gtRNAdb_ID:tRNA-Val-AAC-1-1
Anticodon:ValAAC
tRNA_number:trna2
Chromosome:3
Strand:+
Coordinate:Start Site(bp): 169490018        End Site(bp): 169490048

[4] gtRNAdb_ID:tRNA-Val-AAC-1-4
Anticodon:ValAAC
tRNA_number:trna12
Chromosome:5
Strand:-
Coordinate:Start Site(bp): 180645312        End Site(bp): 180645342

[5] gtRNAdb_ID:tRNA-Val-AAC-1-2
Anticodon:ValAAC
tRNA_number:trna4
Chromosome:5
Strand:+
Coordinate:Start Site(bp): 180591154        End Site(bp): 180591184

[6] gtRNAdb_ID:tRNA-Val-AAC-1-3
Anticodon:ValAAC
tRNA_number:trna5
Chromosome:5
Strand:+
Coordinate:Start Site(bp): 180596610        End Site(bp): 180596640

[7] gtRNAdb_ID:tRNA-Val-AAC-1-5
Anticodon:ValAAC
tRNA_number:trna132
Chromosome:6
Strand:-
Coordinate:Start Site(bp): 27721221        End Site(bp): 27721251

[8] gtRNAdb_ID:tRNA-Val-CAC-5-1
Anticodon:ValCAC
tRNA_number:trna90
Chromosome:1
Strand:-
Coordinate:Start Site(bp): 149684131        End Site(bp): 149684161

[9] gtRNAdb_ID:tRNA-Val-CAC-4-1
Anticodon:ValCAC
tRNA_number:trna98
Chromosome:1
Strand:-
Coordinate:Start Site(bp): 149298597        End Site(bp): 149298627

[10] gtRNAdb_ID:tRNA-Val-CAC-1-1
Anticodon:ValCAC
tRNA_number:trna85
Chromosome:1
Strand:-
Coordinate:Start Site(bp): 161369532        End Site(bp): 161369562

[11] gtRNAdb_ID:tRNA-Val-CAC-1-5
Anticodon:ValCAC
tRNA_number:trna10
Chromosome:5
Strand:-
Coordinate:Start Site(bp): 180649437        End Site(bp): 180649467

[12] gtRNAdb_ID:tRNA-Val-CAC-1-3
Anticodon:ValCAC
tRNA_number:trna18
Chromosome:5
Strand:-
Coordinate:Start Site(bp): 180529295        End Site(bp): 180529325

[13] gtRNAdb_ID:tRNA-Val-CAC-1-2
Anticodon:ValCAC
tRNA_number:trna2
Chromosome:5
Strand:+
Coordinate:Start Site(bp): 180524070        End Site(bp): 180524100

[14] gtRNAdb_ID:tRNA-Val-CAC-1-4
Anticodon:ValCAC
tRNA_number:trna6
Chromosome:5
Strand:+
Coordinate:Start Site(bp): 180600650        End Site(bp): 180600680

[15] gtRNAdb_ID:tRNA-Val-CAC-1-6
Anticodon:ValCAC
tRNA_number:trna9
Chromosome:6
Strand:+
Coordinate:Start Site(bp): 26538282        End Site(bp): 26538312



tsRNA Association Statistics

Total Associated Disease Number:2
More Information
Network:
(Display the first 15 nodes)



Disease Information

 MeSHDisease Ontology
Disease ID:D003928N/A
Disease Name:Diabetic NephropathiesN/A
Category:MeSHDisease Ontology
Type:Urogenital Diseases//Endocrine System DiseasesN/A
Define:KIDNEY injuries associated with diabetes mellitus and affecting KIDNEY GLOMERULUS; ARTERIOLES; KIDNEY TUBULES; and the interstitium. Clinical signs include persistent PROTEINURIA, from microalbuminuria progressing to ALBUMINURIA of greater than 300 mg/24 h, leading to reduced GLOMERULAR FILTRATION RATE and END-STAGE RENAL DISEASE.N/A
Alias:Diabetic Glomerulosclerosis//Diabetic Kidney Disease//Diabetic Nephropathy//Glomerulosclerosis, Diabetic//Intracapillary//Glomerulosclerosis//Kimmelstiel-Wilson Disease//Kimmelstiel-Wilson Syndrome//Nodular GlomerulosclerosisN/A



Disease Association Statistics

Total Associated tsRNA Number:29
More Information
Network:
(Display the first 15 nodes)



Evidence Support

Strong Evidence:RT-PCR
Weak Evidence:High-throughput sequencing



Reference

[1] PubMed ID:37273759
Disease Name:Diabetic Nephropathies
Tissue:Serum samples
Dysfunction Pattern:Up-Regulation
Validated Method:RT-PCR//High-throughput sequencing
Description:Ultimately, six differentially expressed (DE) tRFs were identified (P<0.05; |log2fold change| ≥1), including three upregulated (tRF5-GluCTC, tRF5-AlaCGC and tRF5-ValCAC) and three downregulated tRFs (tRF5-GlyCCC, tRF3-GlyGCC and tRF3-IleAAT).
Comparision:DN VS Diabetes Mellitus
Mechanism:In conclusion, GO analysis suggested that the DE tRFs may be associated with DN pathology.