Entry Detail


General Information

Database ID:TRD03971
Confidence:Median
Contents:>> tsRNA Information
>> tsRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference



tsRNA Information

tsRNA Name:tRF-Tyr-GTA-015
tsRNA Type:tRF-5
Amino acid and Anticodon:TyrGTA
Sequence:CCTTCGATAGCTCAG
Related Target:N/A
Predicted Target:TMED3//SOX11//HIF1AN//HAP1//SRPK1//SYT5//LIN28A//ZMAT3//ZNF862//CHMP7
External Links:
MINTbase ID:N/A
tRFdb ID:tRFdb-5001a



tsRNA Association Statistics

Total Associated Disease Number:3
More Information
Network:
(Display the first 15 nodes)



Disease Information

 MeSHDisease Ontology
Disease ID:D009914DOID:5773
Disease Name:Oral Submucous Fibrosisoral submucous fibrosis
Category:MeSHDisease Ontology
Type:Stomatognathic Diseasesdisease of anatomical entity
Define:Irreversible FIBROSIS of the submucosal tissue of the MOUTH.A mouth disease that is characterized by juxta-epithelial inflammatory reaction and progressive fibrosis of the submucosal tissues.
Alias:N/AOral cavity Submucous Fibrosis//Oral submucosal fibrosis//Oral submucosal fibrosis, including of tongue



Disease Association Statistics

Total Associated tsRNA Number:126
More Information
Network:
(Display the first 15 nodes)



Evidence Support

Strong Evidence:N/A
Weak Evidence:High-throughput sequencing



Reference

[1] PubMed ID:34558114
Disease Name:Oral Submucous Fibrosis
Tissue:Oral Submucous Fibrosis
Dysfunction Pattern:Down-Regulation
Validated Method:High-throughput sequencing
Description:Of 126 tsRNAs in OSF were dysregulated, including 73 upregulated tsRNAs and 53 downregulated tsRNAs. The downregulated tiRNA-Val-CAC-002,tRF-Asn-GTT-005, tRF-Trp-CCA-007 and upregulated tRF-Gly-TCC-016,tRF-Pro-TGG-009 showed significant differences by qRT-PCR validation.
Comparision:Disease VS Control
Mechanism:tRNA-derived fragments are dysregulated and could be involved in the pathogenesis of oral submucous fibrosis.