Entry Detail


General Information

Database ID:TRD03967
Confidence:Very High
Contents:>> tsRNA Information
>> tsRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference



tsRNA Information

tsRNA Name:tRF-58:76-Tyr-GTA-2-M3
tsRNA Type:tRF-5
Amino acid and Anticodon:TyrGTA
Sequence:ATTCCGGCTCGAAGGACCA
Related Target:N/A
Predicted Target:KLHDC4//GAD2//TMEM41A//CHD2//TNR//ATAD1//DUS2//CCDC106//IPO13//RAB11FIP1
External Links:
MINTbase ID:tRF-19-IR69OKE2
tRFdb ID:N/A

[1] gtRNAdb_ID:tRNA-Tyr-GTA-5-3
Anticodon:TyrGTA
tRNA_number:trna19
Chromosome:14
Strand:-
Coordinate:Start Site(bp): 21121258-3        End Site(bp): 21121273

[2] gtRNAdb_ID:tRNA-Tyr-GTA-7-1
Anticodon:TyrGTA
tRNA_number:trna17
Chromosome:14
Strand:-
Coordinate:Start Site(bp): 21128117-3        End Site(bp): 21128132

[3] gtRNAdb_ID:tRNA-Tyr-GTA-5-4
Anticodon:TyrGTA
tRNA_number:trna16
Chromosome:14
Strand:-
Coordinate:Start Site(bp): 21131351-3        End Site(bp): 21131366

[4] gtRNAdb_ID:tRNA-Tyr-GTA-5-5
Anticodon:TyrGTA
tRNA_number:trna5
Chromosome:14
Strand:+
Coordinate:Start Site(bp): 21151505        End Site(bp): 21151520+3

[5] gtRNAdb_ID:tRNA-Tyr-GTA-2-1
Anticodon:TyrGTA
tRNA_number:trna2
Chromosome:2
Strand:+
Coordinate:Start Site(bp): 27273723        End Site(bp): 27273738+3

[6] gtRNAdb_ID:tRNA-Tyr-GTA-5-1
Anticodon:TyrGTA
tRNA_number:trna4
Chromosome:8
Strand:+
Coordinate:Start Site(bp): 67025679        End Site(bp): 67025694+3

[7] gtRNAdb_ID:tRNA-Tyr-GTA-5-2
Anticodon:TyrGTA
tRNA_number:trna5
Chromosome:8
Strand:+
Coordinate:Start Site(bp): 67026296        End Site(bp): 67026311+3



tsRNA Association Statistics

Total Associated Disease Number:1
More Information
Network:
(Display the first 15 nodes)



Disease Information

 MeSHDisease Ontology
Disease ID:N/ADOID:0080216
Disease Name:N/Aduodenal atresia
Category:MeSHDisease Ontology
Type:N/Adisease of anatomical entity
Define:N/AAn intestinal atresia that is characterized by congenital absence or complete closure of a portion of the lumen of the duodenum.
Alias:N/AN/A



Disease Association Statistics

Total Associated tsRNA Number:1
More Information
Network:
(Display the first 15 nodes)



Evidence Support

Strong Evidence:RT-PCR//Western blot//FISH
Weak Evidence:High-throughput sequencing



Reference

[1] PubMed ID:40399722
Disease Name:duodenal atresia
Tissue:Bowel
Dysfunction Pattern:N/A
Validated Method:RT-PCR//Western blot//FISH//High-throughput sequencing
Description:During the biomarker screening period, tRF-58:76-Tyr-GTA-2-M3 demonstrated the highest diagnostic accuracy. Our investigation focused on tRF-58:76-Tyr-GTA-2-M3 to ascertain its potential role in DA development. Accordingly, we investigated the expression of tRF-58:76-Tyr-GTA-2-M3 and apoptosis-related proteins in four paired duodenal specimens from DA and normal fetuses.
Comparision:Disease VS Control
Mechanism:In vitro experiments in NCM460 cells indicated that SUFU silencing induced apoptosis, as demonstrated by remarkable alteration in the expression of apoptosis-related proteins. TRF-58:76-Tyr-GTA-2-M3 was predicted to target the 3′-UTR of SUFU, which was subsequently validated using a luciferase reporter assay. These findings suggested that tRF-58:76-Tyr-GTA-2-M3 may cause DA by inhibiting SUFU expression.