Entry Detail


General Information

Database ID:TRD03835
Confidence:High
Contents:>> tsRNA Information
>> tsRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference



tsRNA Information

tsRNA Name:tRF-Pro-AGG-004
tsRNA Type:tRF-5
Amino acid and Anticodon:ProAGG;ProCGG;ProTGG
Sequence:GGCTCGTTGGTCTAGGGGTATGATTCTCGC
Related Target:N/A
Predicted Target:KCNJ4//NOMO3//NOMO2//STAB2//BLMH//PTPRU//ZSWIM8//D2HGDH//MAN1C1//PRDM7
External Links:
MINTbase ID:tRF-30-6978WPRLXN4V
tRFdb ID:N/A

[1] gtRNAdb_ID:tRNA-Pro-AGG-2-1
Anticodon:ProAGG
tRNA_number:trna65
Chromosome:1
Strand:-
Coordinate:Start Site(bp): 167684767        End Site(bp): 167684796

[2] gtRNAdb_ID:tRNA-Pro-AGG-2-4
Anticodon:ProAGG
tRNA_number:trna9
Chromosome:11
Strand:+
Coordinate:Start Site(bp): 75946557        End Site(bp): 75946586

[3] gtRNAdb_ID:tRNA-Pro-AGG-2-6
Anticodon:ProAGG
tRNA_number:trna22
Chromosome:14
Strand:-
Coordinate:Start Site(bp): 21081602        End Site(bp): 21081631

[4] gtRNAdb_ID:tRNA-Pro-AGG-2-5
Anticodon:ProAGG
tRNA_number:trna23
Chromosome:14
Strand:-
Coordinate:Start Site(bp): 21077537        End Site(bp): 21077566

[5] gtRNAdb_ID:tRNA-Pro-AGG-2-7
Anticodon:ProAGG
tRNA_number:trna29
Chromosome:16
Strand:-
Coordinate:Start Site(bp): 3232677        End Site(bp): 3232706

[6] gtRNAdb_ID:tRNA-Pro-AGG-2-8
Anticodon:ProAGG
tRNA_number:trna9
Chromosome:16
Strand:+
Coordinate:Start Site(bp): 3239634        End Site(bp): 3239663

[7] gtRNAdb_ID:tRNA-Pro-AGG-2-2
Anticodon:ProAGG
tRNA_number:trna12
Chromosome:6
Strand:+
Coordinate:Start Site(bp): 26555498        End Site(bp): 26555527

[8] gtRNAdb_ID:tRNA-Pro-AGG-2-3
Anticodon:ProAGG
tRNA_number:trna2
Chromosome:7
Strand:+
Coordinate:Start Site(bp): 128423504        End Site(bp): 128423533

[9] gtRNAdb_ID:tRNA-Pro-AGG-1-1
Anticodon:ProAGG
tRNA_number:trna11
Chromosome:16
Strand:+
Coordinate:Start Site(bp): 3241989        End Site(bp): 3242018

[10] gtRNAdb_ID:tRNA-Pro-CGG-2-1
Anticodon:ProCGG
tRNA_number:trna30
Chromosome:6
Strand:+
Coordinate:Start Site(bp): 27059521        End Site(bp): 27059550

[11] gtRNAdb_ID:tRNA-Pro-CGG-1-1
Anticodon:ProCGG
tRNA_number:trna52
Chromosome:1
Strand:+
Coordinate:Start Site(bp): 167683962        End Site(bp): 167683991

[12] gtRNAdb_ID:tRNA-Pro-CGG-1-2
Anticodon:ProCGG
tRNA_number:trna6
Chromosome:16
Strand:+
Coordinate:Start Site(bp): 3222049        End Site(bp): 3222078

[13] gtRNAdb_ID:tRNA-Pro-CGG-1-3
Anticodon:ProCGG
tRNA_number:trna37
Chromosome:17
Strand:-
Coordinate:Start Site(bp): 8126193        End Site(bp): 8126222

[14] gtRNAdb_ID:tRNA-Pro-TGG-3-2
Anticodon:ProTGG
tRNA_number:trna6
Chromosome:14
Strand:+
Coordinate:Start Site(bp): 21152175        End Site(bp): 21152204

[15] gtRNAdb_ID:tRNA-Pro-TGG-3-4
Anticodon:ProTGG
tRNA_number:trna28
Chromosome:16
Strand:-
Coordinate:Start Site(bp): 3234175        End Site(bp): 3234204

[16] gtRNAdb_ID:tRNA-Pro-TGG-3-3
Anticodon:ProTGG
tRNA_number:trna3
Chromosome:16
Strand:+
Coordinate:Start Site(bp): 3208923        End Site(bp): 3208952

[17] gtRNAdb_ID:tRNA-Pro-TGG-3-5
Anticodon:ProTGG
tRNA_number:trna8
Chromosome:16
Strand:+
Coordinate:Start Site(bp): 3238094        End Site(bp): 3238123

[18] gtRNAdb_ID:tRNA-Pro-TGG-3-1
Anticodon:ProTGG
tRNA_number:trna14
Chromosome:5
Strand:-
Coordinate:Start Site(bp): 180615896        End Site(bp): 180615925



tsRNA Association Statistics

Total Associated Disease Number:29
More Information
Network:
(Display the first 15 nodes)



Disease Information

 MeSHDisease Ontology
Disease ID:D009765DOID:9970
Disease Name:Obesityobesity
Category:MeSHDisease Ontology
Type:Nutritional and Metabolic Diseases//Pathological Conditions, Signs and Symptomsdisease of metabolism
Define:A status with BODY WEIGHT that is grossly above the recommended standards, usually due to accumulation of excess FATS in the body. The standards may vary with age, sex, genetic or cultural background. In the BODY MASS INDEX, a BMI greater than 30.0 kg/m2 is considered obese, and a BMI greater than 40.0 kg/m2 is considered morbidly obese (MORBID OBESITY).An overnutrition that is characterized by excess body fat, traditionally defined as an elevated ratio of weight to height (specifically 30 kilograms per meter squared), has_material_basis_in a multifactorial etiology related to excess nutrition intake, decreased caloric utilization, and genetic susceptibility, and possibly medications and certain disorders of metabolism, endocrine function, and mental illness.
Alias:N/AN/A



Disease Association Statistics

Total Associated tsRNA Number:55
More Information
Network:
(Display the first 15 nodes)



Evidence Support

Strong Evidence:RT-PCR
Weak Evidence:High-throughput sequencing



Reference

[1] PubMed ID:37352601
Disease Name:Obesity
Tissue:Brown Adipocytes
Dysfunction Pattern:Down-Regulation
Validated Method:RT-PCR//High-throughput sequencing
Description:Further, qRT-PCR validated that three notably upregulated tRFs (tRF-Gly-GCC-007, tRF-Gly-GCC-008, and tRF-Gly-GCC-013) were in accordance with the sequencing result.
Comparision:Forskolin VS Control
Mechanism:Target genes of tRFs were involved in positive regulation of protein phosphorylation and cell adhesion process by significantly downregulating UCHL7 expression, which might participate in lipolysis. This study might provide therapeutic targets and potential diagnostic biomarkers for obesity treatment.